Ventral Striatal Activation During Reward Anticipation Correlates with Impulsivity in Alcoholics
Ventral Striatal Activation During Reward Anticipation Correlates with Impulsivity in Alcoholics
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DOI：
10.1016/j.biopsych.2009.04.035
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发表时间：
2009-10-15
影响因子：
10.6
通讯作者：
Wrase, Jana
中科院分区：
文献类型：
--
作者：
Beck, Anne;Schlagenhauf, Florian;Wrase, Jana
背景：酒精依赖常与冲动性有关，而冲动性可能与大脑奖赏系统功能障碍有关。我们探讨了在预期激励刺激的过程中，功能性大脑激活是否与脱毒酗酒者和健康对照受试者的冲动有关。19名戒酒的男性酗酒者和19名年龄匹配的健康男性参加了一项功能性磁共振成像（fMRI）研究，该研究使用了货币激励延迟（MID）任务，其中视觉线索预测对后续目标刺激的快速反应要么会带来金钱收益、避免金钱损失，要么不会产生任何后果。冲动与Barratt冲动量表版本10（BIS-10）进行了评估。结果：与健康对照组相比，戒酒者在预期金钱收益时腹侧纹状体的激活减少。低激活腹侧纹状体和前扣带回在增益预期与高冲动只有在酗酒者，而不是在control subjects.Conclusions：本研究表明，减少腹侧纹状体招聘在酗酒者的传统奖励预期可能与他们的冲动增加，并表明可能性增强酒精依赖的治疗方法。
Background: Alcohol dependence is often associated with impulsivity, which may be correlated with dysfunction of the brain reward system. We explored whether functional brain activation during anticipation of incentive stimuli is associated with impulsiveness in detoxified alcoholics and healthy control subjects.Methods: Nineteen detoxified male alcoholics and 19 age-matched healthy men participated in a functional magnetic resonance imaging (fMRI) study using a monetary incentive delay (MID) task, in which visual cues predicted that a rapid response to a subsequent target stimulus would either result in monetary gain, avoidance of monetary loss, or no consequence. Impulsivity was assessed with the Barratt Impulsiveness Scale-Version 10 (BIS-10).Results: Detoxified alcoholics showed reduced activation of the ventral striatum during anticipation of monetary gain relative to healthy control subjects. Low activation of the ventral striatum and anterior cingulate during gain anticipation was correlated with high impulsivity only in alcoholics, not in control subjects.Conclusions: This study suggests that reduced ventral striatal recruitment during anticipation of conventional rewards in alcoholics may be related to their increased impulsivity and indicate possibilities for enhanced treatment approaches in alcohol dependence.