Risk of adverse birth outcome after group B meningococcal disease: results from a Danish national cohort.
Risk of adverse birth outcome after group B meningococcal disease: results from a Danish national cohort.
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B 组脑膜炎球菌病后不良出生结局的风险：丹麦国家队列的结果。
DOI：
10.1097/inf.0b013e31818c9049
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Miller,MarkA
中科院分区：
文献类型：
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作者：
Howitz,MichaelF;Simonsen,Jacob;Krause,TyraGrove;Robbins,JohnB;Schneerson,Rachel;Molbak,Kare;Miller,MarkA
背景：B 组脑膜炎球菌 (GBM) 疾病会诱导抗体在体外与胎儿脑组织中的神经细胞粘附分子发生反应。由于 GBM IgG 抗体会穿过胎盘，因此作者调查了既往患有 GBM 疾病的女性是否会增加早产或死产婴儿的风险，以及活产婴儿出生缺陷的风险是否会增加。 方法：从 1974 年至 2005 年期间从 4 个国家登记处获得数据，形成 2 个队列：(1) 1422 名确诊患有 GBM 疾病的女性，(2) 她们的 502 名长子结果：总体而言，第一组中早产或死产的风险没有增加。在这些儿童中，出生小于胎龄、出生缺陷（OR：1.00；95% CI：0.53-1.90）、神经系统疾病（HR：0.38；95% CI：0.08-1.74）或生命前 3 年内任何疾病（HR：1.06；95% CI： 0.78–1.45）与先前患有 C 组脑膜炎球菌病的参考人群的出生相比。结论：结果不支持 GBM 与可能影响后代健康的免疫反应性疾病相关的观点，并且与之前的研究结果一致，即 GBM 疾病与自身免疫性疾病风险增加无关。
Background:Group B meningococcal (GBM) disease induces antibodies that react in vitro with neural cell adhesion molecules in fetal brain tissue. Because IgG antibodies to GBM cross the placenta, the authors investigated whether women with a previous GBM disease had an increased risk of giving birth to preterm or to stillborn infants and whether the live-born children had an increased risk of birth defects.Methods:Data were obtained from 4 national registries in the period 1974–2005 to form 2 cohorts:(1) 1422 women with confirmed GBM disease, and (2) their 502 firstborn children.Results:Overall, there was no increased risk of preterm or stillbirths among the first cohort. Among the children, there was no increased risk of being born small for the gestational age, having birth defects (OR: 1.00; 95% CI: 0.53–1.90), diseases of the nervous system (HR: 0.38; 95% CI: 0.08–1.74), or any diseases within the first 3 years of life (HR: 1.06; 95% CI: 0.78–1.45) compared to births from a reference population with prior group C meningococcal disease.Conclusions:The results do not support the proposal that GBM is associated with immunoreactive disease that may affect the health of the offspring and are consistent with previous findings that GBM disease is not associated with an increased risk of autoimmune disease.