Principles of Information Storage in Small-Molecule Mixtures
Principles of Information Storage in Small-Molecule Mixtures
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DOI：
10.1109/tnb.2020.2977304
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发表时间：
2020-07-01
影响因子：
3.9
通讯作者：
Rubenstein, Brenda M.
中科院分区：
文献类型：
--
作者：
Rosenstein, Jacob K.;Rose, Christopher;Rubenstein, Brenda M.
分子数据系统有潜力以比现有电子介质高得多的密度存储信息。这一想法的一些最初的实验演示使用了DNA，但自然界也使用各种各样较小的非聚合分子来保存、处理和传递信息。在本文中，我们提出了一个量化化学记忆的通用框架，它不限于聚合物，还延伸到所有类型分子的混合物。我们表明，分子信息的理论极限按质量比DNA密集两个数量级，尽管这在总容量方面伴随着不同的实际限制。我们通过实验证明了在小型合成分子的混合物中千字节规模的信息存储，并且我们考虑了一些利用来自广阔的非基因组化学空间的可用信息容量所必需的新视角。
Molecular data systems have the potential to store information at dramatically higher density than existing electronic media. Some of the first experimental demonstrations of this idea have used DNA, but nature also uses a wide diversity of smaller non-polymeric molecules to preserve, process, and transmit information. In this paper, we present a general framework for quantifying chemical memory, which is not limited to polymers and extends to mixtures of molecules of all types. We show that the theoretical limit for molecular information is two orders of magnitude denser by mass than DNA, although this comes with different practical constraints on total capacity. We experimentally demonstrate kilobyte-scale information storage in mixtures of small synthetic molecules, and we consider some of the new perspectives that will be necessary to harness the information capacity available from the vast non-genomic chemical space.