Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
复制标题
先天淋巴样细胞会整合基质和免疫信号，从而增强脾脏边缘区B细胞的抗体产生。
作者：
先天性淋巴样细胞（ILC）调节基质细胞、上皮细胞和免疫细胞，但它们对B细胞的影响尚不清楚。我们在边缘区（MZ）附近发现了RORγt+ ILC，边缘区是一个脾区室，含有对循环T细胞非依赖性（TI）抗原应答的先天性B细胞。脾ILC通过提供肿瘤坏死因子（TNF）和α光毒素与MAdCAM-1+边缘网状细胞建立双向串扰，并通过BAFF、CD 40配体和Notch配体δ样1激活MZ B细胞。脾ILC通过释放GM-CSF来吸收中性粒细胞，从而进一步帮助MZ B细胞及其浆细胞后代。因此，ILC耗竭损害免疫前和免疫后TI抗体应答。因此，ILC整合基质和骨髓信号以在免疫系统和循环系统之间的界面处协调天然样抗体的产生。
Innate lymphoid cells (ILCs) regulate stromal, epithelial and immune cells, but their impact on B cells remains unclear. We identified RORγt+ ILCs nearby the marginal zone (MZ), a splenic compartment containing innate-like B cells that respond to circulating T cell-independent (TI) antigens. Spenic ILCs established a bidirectional crosstalk with MAdCAM-1+ marginal reticular cells by providing tumor necrosis factor (TNF) and lymphotoxin, and activated MZ B cells via BAFF, CD40 ligand and the Notch ligand, Delta-like 1. Splenic ILCs further helped MZ B cells and their plasma cell progeny by co-opting neutrophils through the release of GM-CSF. Consequently, ILC depletion impaired both pre- and post-immune TI antibody responses. Thus, ILCs integrate stromal and myeloid signals to orchestrate innate-like antibody production at the interface between the immune and circulatory systems.
登录
查看更多内容
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
64.5
作者：
Kang, YS;Do, YY;Park, CG
通讯作者：
Park, CG
影响因子：
30.5
作者：
Manel, Nicolas;Unutmaz, Derya;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
30.5
作者：
Guinamard, R;Okigaki, M;Ravetch, JV
通讯作者：
Ravetch, JV