The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women.
The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women.
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年龄对正常和骨质疏松女性血清免疫反应性甲状旁腺激素的影响。
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
C. Arnaud
中科院分区：
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作者：
J. Gallagher;B. Riggs;C. Jerpbak;C. Arnaud
在大量正常和骨质疏松妇女中测定血清iPTH随年龄的变化，使用三种抗血清进行放射免疫测定：GP-1M，主要识别PTH的44- 68个氨基酸序列内的一个区域；CH-12M，似乎主要识别完整的激素；CH-14M主要识别PTH的1—34个氨基酸序列内的一个区域。在20 ~ 90岁的正常女性中，血清iPTH随年龄的增长而显著升高（p < 0.001）；抗血清GP-1M组（80%）比抗血清CH-12M组（30%）的比例增加更大，说明循环甲状旁腺激素羧基片段的增加大于循环完整甲状旁腺激素的增加。在40例绝经后骨质疏松患者中，抗血清GP-1M测定的血清iPTH平均值与年龄匹配的正常女性无显著差异；然而，三名骨质疏松症患者的数值升高，因此似乎代表了一个单独的人群。当这些受试者被排除在外时，抗血清GP-1M测定的平均血清iPTH也低于正常水平（p < 0.001）。用抗血清CH-12M （p < 0.001）或抗血清CH-14M （p < 0.001）测定骨质疏松症患者血清iPTH的平均值均低于正常人。骨质疏松组PTH功能指标血清磷酸盐和肾小管磷酸盐吸收值升高（p < 0.005）。尽管在正常和骨质疏松的受试者中，肌酐清除率都随着年龄的增长而下降，但与年龄保持不变的部分相关性表明，肌酐清除率与血清iPTH之间没有关系。这表明肾功能下降并不是导致血清iPTH随年龄升高的主要因素。我们得出结论，血清iPTH随着年龄的增长而增加，但对于任何给定的年龄，绝经后骨质疏松症患者的iPTH要么正常，要么低。
Serum iPTH was measured in a large series of normal and osteoporotic women as a function of age, with radioimmunoassays using three antisera: GP-1M, which recognizes primarily a region within the 44--68 amino acid sequence of PTH; CH-12M, which appears to recognize primarily intact hormone; and CH-14M, which recognizes primarily a region within the 1--34 amino acid sequence of PTH. In normal women 20 to 90 years of age, serum iPTH increased significantly with age (p less than 0.001); the proportional increase was greater when measured with antiserum GP-1M (80%) than when measured with antiserum CH-12M (30%), which suggests that the increase in circulating carboxyl fragments of PTH was greater than the increase in circulating intact PTH. In 40 patients with postmenopausal osteoporosis, the mean value for serum iPTH assayed by antiserum GP-1M did not differ significantly from that for age-matched normal women; however, three osteoporotic patients had elevated values and thus appear to represent a separate population. When these subjects were excluded, mean serum iPTH assayed by antiserum GP-1M also was lower than normal (p less than 0.001). The mean value for serum iPTH was lower in osteoporotic patients than in normal subjects when assayed by either antiserum CH-12M (p less than 0.001) or antiserum CH-14M (p less than 0.001). Values for serum phosphate and renal tubular phosphate resorption, both indices of PTH function, were increased (p less than 0.005) in the osteoporotic subjects. Although creatinine clearance decreased with age in both normal and osteoporotic subjects, partial correlations with age held constant showed no relationship between creatinine clearance and serum iPTH. This suggests that a decrease in renal function was not the major factor accounting for the rise in serum iPTH with age. We conclude that serum iPTH increases with aging but that for any given age, it is either normal or low in patients with postmenopausal osteoporosis.