Initial e-cigarette flavoring and nicotine exposure and e-cigarette uptake among adolescents
Initial e-cigarette flavoring and nicotine exposure and e-cigarette uptake among adolescents
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DOI：
10.1016/j.drugalcdep.2019.04.037
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发表时间：
2019-09-01
影响因子：
4.2
通讯作者：
Alexander, Emily
中科院分区：
文献类型：
--
作者：
Audrain-McGovern, Janet;Rodriguez, Daniel;Alexander, Emily
目的：电子烟是青少年使用最普遍的烟草产品。我们试图确定第一次接触电子烟时香料和/或尼古丁的存在是否可以预测青少年中当前电子烟使用的进展(过去30天内使用)以及使用的升级(过去30天内的天数)。方法：来自宾夕法尼亚州费城以外的公立高中的青少年在接下来的18个月里(2018年秋季，11年级开始)完成了基线(9年级)和6个月间隔的课堂调查。在基线水平(N=354)报告使用过电子烟的青少年构成了分析样本。结果：我们采用了一个包括味道、尼古丁和其他协变量的两部分潜在增长曲线模型。在接下来的18个月里，最初使用有香料(与无香料)的电子烟与发展到现在的电子烟使用(Beta=0.54，z=2.09，p=0.04)和电子烟使用天数的增加(Beta=0.35，z=2.58，p=0.01)相关。首次使用含有尼古丁的电子烟(与不含尼古丁的电子烟相比)与基线时使用电子烟的天数较多相关(beta=0.49，z=2.16，p=0.03)。结论：这些发现强调了香料和尼古丁对电子烟初始使用以外的进展的风险。针对电子烟中的调味品和尼古丁的法规可能会减少目前和经常使用电子烟的青少年数量。
Objective: E-cigarettes are the most prevalent tobacco product used by adolescents. We sought to determine whether the presence of flavoring and/or the presence of nicotine at the first e-cigarette exposure predicted progression to current e-cigarette use (use in past 30 days) as well as escalation in use (number of days in the past 30 days) among adolescents.Methods: Adolescents from public high schools outside of Philadelphia, PA completed in-classroom surveys at baseline (9th grade) and at 6-month intervals for the following 18 months (fall 2018, beginning of 11th grade). Adolescents who reported ever having used e-cigarettes at baseline (N = 354) comprised the analytical sample.Results: We employed a two-part Latent Growth Curve Model including flavor, nicotine, and other covariates. Initial use of a flavored (vs unflavored) e-cigarette was associated with progression to current e-cigarette use (beta = 0.54, z = 2.09, p = 0.04) and escalation in the number of days of e-cigarette use (beta = 0.35, z = 2.58, p = 0.01) across the following 18 months. Initial use of an e-cigarette with nicotine (vs without nicotine) was associated with a greater number of days of e-cigarette use at baseline (beta = 0.49, z = 2.16, p = 0.03).Conclusions: The findings underscore the risk that flavoring and nicotine pose for progression beyond initial e-cigarette use. Regulations addressing flavoring and nicotine in e-cigarettes have the potential to reduce the number of adolescents who become current as well as frequent e-cigarette users.