DNA markers and genetic variation in the human species.
DNA markers and genetic variation in the human species.
复制标题
DNA 标记和人类物种的遗传变异。
DOI：
10.1101/sqb.1986.051.01.049
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Freidlaender,JS
中科院分区：
文献类型：
--
作者：
Cavalli-Sforza,LL;Kidd,JR;Kidd,KK;Bucci,C;Bowcock,AM;Hewlett,BS;Freidlaender,JS
方法人群选择。感兴趣的人群有两种类型：传统人群和现代人群。在传统人群中，显然选择应该是那些很少或没有最近混合的人群。对于美国本地人来说，这可能会大大限制选择。如果外加剂是古老的，可以忽略不计；在某种程度上，所有人群都有某种混合。现代人口可能最能代表农村地区，那里的人口混合程度可能比城市地区少。不幸的是，在收集东方样本时，我们还无法应用这一规则，稍后将指出。储存样本、提取 DNA 和测试探针的成本非常高，即使理想的采样方案在实践中特别难以实施，也必须制定程序以获得最佳结果。
METHODSSelection of populations. There are two types of populations of interest: traditional and modern. Among traditional ones, clearly the choice should be populations that have little, or no, recent admixture. For American natives this may limit the choice considerably. If the admixture is ancient, it can be neglected; at some level, all populations have had some admixture. Modern populations are probably best represented in rural areas where there is likely to be less admixture than in urban areas. Unfortunately, in collecting our Oriental samples we have been, as yet, unable to apply this rule, as will be indicated later. Storing the samples, extracting DNA, and testing the probes are so costly that procedures will have to be developed for optimal results even if the ideal sampling scheme is especially difficult to carry out in practice.