Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs
Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs
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DOI：
10.1016/s0006-3223(02)01574-3
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发表时间：
2003-02-15
影响因子：
10.6
通讯作者：
Sharp, T
中科院分区：
文献类型：
--
作者：
Singewald, N;Salchner, P;Sharp, T
背景资料：事实上，焦虑和恐慌相关症状的诱导是一系列药物的共同特性，这表明共同的神经基质是其行为效应的基础。（FG-7142、育亨宾、氯苯基哌嗪[mCPP]和咖啡因）对大鼠前脑中焦虑相关回路的影响。所有四种药物通常增加Fos样免疫反应在7的41个脑区的调查，即中央核的杏仁核，床核的终纹，外侧隔，室旁核的下丘脑，外侧下丘脑，边缘下和边缘前皮质。所有的药物，但一个（mCPP）也增加Fos的表达在基底外侧和内侧杏仁核，背内侧下丘脑，扣带回皮质，和部分的运动cortic.Conclusions：结果表明，选择的抗焦虑药物激活一组有限的前脑区。这些区域中的大多数先前已经被证明是由环境诱发的焦虑激活的，并且与被相同的药物和环境诱发的焦虑激活的后脑区域有解剖学上的联系。总之，这些数据是一致的整合前脑和后脑神经元系统的理论，这是重要的药物和环境操纵引起的焦虑状态。(C)2003生物精神病学学会。
Background: The fact that induction of anxiety- and panic-related symptoms is a property common to a range of drugs suggests that common neural substrates underlie their behavioral effects.Methods: We used Fos immunocytochemistry to test the effects of four anxiogenic drugs (FG-7142, yohimbine, in-chlorophenylpiperazine [mCPP], and caffeine) on anxiety-related circuitry in rat forebrain.Results: All four drugs commonly increased Fos-like immunoreactivity in 7 of 41 brain areas investigated, namely, central nucleus of the amygdala, bed nucleus of the stria terminalis, lateral septum, paraventricular nucleus of the hypothalamus, lateral hypothalamus, infralimbic and prelimbic cortex. All drugs but one (mCPP) also increased Fos expression in the basolateral and medial amygdala, the dorsomedial hypothalamus, cingulate cortex, and parts of the motor cortex.Conclusions: The results suggest that the anxiogenic drugs selected activate a restricted set of forebrain areas. Most of these areas have previously been shown to be activated by environmentally evoked anxiety and to have anatomic connections with hindbrain regions that are activated by the same drugs and by environmentally evoked anxiety. Together, these data are consistent with the theory of an integrated forebrain and hindbrain neuronal system that is important for anxiety states evoked by both drug and environmental manipulations. (C) 2003 Society of Biological Psychiatry.