NUCLEOTIDE-SEQUENCES OF 2 SERINE TRANSFER-RNAS WITH A GGA ANTICODON - THE STRUCTURE-FUNCTION-RELATIONSHIPS IN THE SERINE FAMILY OF ESCHERICHIA-COLI TRANSFER-RNAS
NUCLEOTIDE-SEQUENCES OF 2 SERINE TRANSFER-RNAS WITH A GGA ANTICODON - THE STRUCTURE-FUNCTION-RELATIONSHIPS IN THE SERINE FAMILY OF ESCHERICHIA-COLI TRANSFER-RNAS
复制标题
DOI：
10.1093/nar/13.15.5697
复制
发表时间：
1985-01-01
影响因子：
14.9
通讯作者：
CEDERGREN, R
中科院分区：
文献类型：
--
作者：
GROSJEAN, H;NICOGHOSIAN, K;CEDERGREN, R
We have determined the nucleotide sequence of the major species ofE.colitRNASerand of a minor species having the same GGA anticodon. These two tRNAs should recognize the UCC and UCU codons, the most widely used codons for serine in the highly expressed genes ofE.coli. The two sequences differ in only one position of the D-loop. Neither tRNA has a modified adenosine in the position 3′-adjacent to the anticodon. This can be rationalized on the basis of a structural constraint in the anticodon stem and may be related to optimization of the codon-anticodon interaction. Conparison of allE.coliserine tRNAs (and that encoded by bacteriophage T4) reveals characteristic (possibly functional) features. Evolutionary analysis suggests an eubacterial origin of the T4tRNASergene and the existences of a recent common ancestor for theandgenes.
