Compliance of an apatitic calcium phosphate cement with the short-term clinical requirements in bone surgery, orthopaedics and dentistry
Compliance of an apatitic calcium phosphate cement with the short-term clinical requirements in bone surgery, orthopaedics and dentistry
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DOI：
10.1016/0267-6605(94)90018-3
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
Driessens, F. C. M.
中科院分区：
文献类型：
--
作者：
Ginebra, M. P.;Fernandez, E.;Driessens, F. C. M.
开发了一种磷灰石磷酸钙骨水泥，其粉末中含有成核剂，液体中含有促进剂，根据吉尔莫尔针在室温下的测试，初凝时间为7.5分钟，最终凝结时间为12.5分钟。在体温下，初始凝固时间为 6 分钟，之后即可闭合伤口。面团时间（在此期间面团可以变形而不破坏其微观结构）为4分钟。因此，使用该材料进行操作期间损失的时间为 2 分钟。产品在凝固过程中不收缩、不膨胀，也无热效应；在初始凝固后，它在暴露于水性液体时不会膨胀或分解。在林格氏溶液中浸泡后，产品获得 40 MPa 的最终抗压强度，并且在体温下 6 小时内达到该强度的 65%。不存在细胞毒性。设想在骨外科、骨科和牙科等领域应用。用于加速金属内置假体的骨整合。
An apatitic calcium phosphate cement was developed containing a nucleator in its powder and an accelerator in the liquid and having an initial setting time of 7.5 min and a final setting time of 12.5 min according to testing with Gillmore needles at room temperature. At body temperature the initial setting time is 6 min, after which the wound can be closed. The dough time (during which it can be deformed without damaging its microstructure) is 4 min. Therefore, the time lost during an operation with this material is 2 min. The product does not shrink or expand during setting, neither is there a thermal effect; it does not swell or disintegrate upon exposure to aqueous fluids after initial setting. Upon soaking in Ringer's solution the product obtains a final compressive strength of 40 MPa and 65% of that strength is reached within 6 h at body temperature. Cytotoxicity is absent. Applications are envisaged in bone surgery, orthopaedics and dentistry, a.o. for acceleration of the osseointegration of metal endoprostheses.