Optimizing the Protocol for Pulmonary Cryoablation: A Comparison of a Dual- and Triple-Freeze Protocol
Optimizing the Protocol for Pulmonary Cryoablation: A Comparison of a Dual- and Triple-Freeze Protocol
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DOI：
10.1007/s00270-010-9868-0
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发表时间：
2010-12-01
影响因子：
2.9
通讯作者：
Brace, Christopher L.
中科院分区：
文献类型：
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作者：
Hinshaw, J. Louis;Littrup, Peter J.;Brace, Christopher L.
本研究的目的是比较两种冻融方案和三种冻融方案在猪体内肺模型中的应用。我们利用经皮技术对正常猪肺进行了18例冻融手术，其中两种方案（10-10-10）和三种方案（3-3-7-7-5）各9例，在消融过程中获得了一系列非对比CT图像，并回顾了CT成像结果和病理然而，在第一次解冻周期中，两种方案的探针周围都出现了磨砂玻璃不透明区域。由于三次冻融方案的初始冻结时间较短，因此该方案的成像结果较早显现（6 vs 13分钟）。尽管总冻结时间较短（15分钟vs 20分钟），三次冻融方案确定的消融区与两次冻融方案没有显著差异(平均直径1 67 +/- 0 41 cm vs 1 66 +/- 0 21 cm P = 0.77，面积21 +/- 0 48 cm（2) vs 1 99 +/- 062 cm(2), P = 07，圆度0 95 +/- 0 04 vs 0 96 +/- 0 03）。P = 0.62)这项研究表明，三重冻融方案可能有几个优点，包括更早地识别与消融相关的影像学表现，更短的手术时间或更大的消融区域，理论上，与额外的冻融周期相关的更有效的细胞毒性。
The purpose of this study was to compare a double freeze thaw protocol to a triple freeze thaw protocol for pulmonary cryoablation utilizing an in vivo porcine lung model A total of 18 cryoablations were performed in normal porcine lung utilizing percutaneous technique with 9 each in a double- (10-5-10) and triple-freeze (3-3-7-7-5) protocol Serial noncontrast CT images were obtained during the ablation CT imaging findings and pathology were reviewed No imaging changes were identified during the initial freeze cycle with either protocol However, during the first thaw cycle, a region of ground glass opacity developed around the probe with both protocols Because the initial freeze was shorter with the triple freeze thaw protocol, the imaging findings were apparent sooner with this protocol (6 vs 13 min) Also, despite a shorter total freeze time (15 vs 20 min) the ablation zone identified with the triple freeze thaw protocol was not significantly different from the double freeze thaw protocol (mean diameter 1 67 +/- 0 41 cm vs 1 66 +/- 0 21 cm P = 0 77, area 2 1 +/- 0 48 cm(2) vs 1 99 +/- 062 cm(2), P = 07, and circularity 0 95 +/- 0 04 vs 0 96 +/- 0 03, P = 0 62 respectively) This study suggests that there may be several advantages of a triple freeze thaw protocol for pulmonary cryoablation including earlier identification of the imaging findings associated with the ablation the promise of a shorter procedure time or larger zones of ablation, and theoretically, more effective cytotoxicity related to the additional freeze-thaw cycle.