Epidemiological characterization of influenza A(H1N1)pdm09 cases from 2009 to 2010 in Baguio City, the Philippines.
Epidemiological characterization of influenza A(H1N1)pdm09 cases from 2009 to 2010 in Baguio City, the Philippines.
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DOI：
10.1371/journal.pone.0079916
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tallo VL
中科院分区：
文献类型：
--
作者：
Pamaran RR;Kamigaki T;Hewe TT;Flores KM;Mercado ES;Alday PP;Tan AG;Oshitani H;Olveda RM;Tallo VL
菲律宾碧瑶市于2009年5月经历了首例甲型H1N1流感pdm09[A(H1)pdm09]病例。尽管有许多报告描述了A(H1)pdm09病例的流行病学和临床特征，但在菲律宾没有关于全年观察到流感活动的A(H1)pdm09流行病学研究。我们的目的是调查甲型H1pdm09在大流行和大流行后的流行病学和临床特征。数据是在2009年1月至2010年12月加强监测流感样疾病(ILI)和严重急性呼吸道感染(SARI)的情况下收集的。按照美国疾病控制和预防中心的方案，用RT-PCR检测A(H1)pdm09。繁殖量按简单的指数增长率计算。比例和分类数据的差异采用卡方检验或Fishers‘s精确检验。2009年第25至35周和2010年第24至37周分别观察到暴发。病例比例最高的是5-14岁的儿童。2009年的ILI门诊患者数量是2010年的2.3倍，而2009年的住院患者数量是2010年的1.8倍。在这两个时期中，没有观察到显著的性别差异。所有患者的临床情况总体上是轻微的和自我限制的，2009年住院患者中只有2人死亡。在平均世代时间为2.6天的假设下，2009年和2010年的基本繁殖数分别估计为1.16和1.05。学龄儿童在促进流感传播方面发挥了重要作用。
Baguio City, Philippines experienced its first influenza A(H1N1)pdm09 [A(H1)pdm09] case in May 2009. In spite of numerous reports describing the epidemiological and clinical features of A(H1)pdm09 cases, there are no studies about A(H1)pdm09 epidemiology in the Philippines, where year-round influenza activity was observed. We aimed to investigate the epidemiological and clinical features of A(H1)pdm09 in pandemic and post-pandemic periods. Data were collected under enhanced surveillance of influenza-like illness (ILI) and severe acute respiratory infection (SARI) from January 2009 to December 2010. RT-PCR was used to detect A(H1)pdm09, following the protocol of the United States Centers for Disease Control and Prevention. The reproduction number was computed as a simple exponential growth rate. Differences in proportional and categorical data were examined using chi-square test or Fishers’ exact test. The outbreak was observed from week 25 to 35 in 2009 and from week 24 to 37 in 2010. The highest proportion of cases was among children aged 5–14 years. The number of ILI outpatients was 2.3-fold higher in 2009 than in 2010, while the number of inpatients was 1.8-fold higher in 2009. No significant difference in gender was observed during the two periods. The clinical condition of all patients was generally mild and self-limiting, with only 2 mortalities among inpatients in 2009. The basic reproduction number was estimated as 1.16 in 2009 and 1.05 in 2010 in the assumption of mean generation time as 2.6 days. School children played a significant role in facilitating influenza transmission.
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影响因子：
5
作者：
Schanzer D;Vachon J;Pelletier L
通讯作者：
Pelletier L
DOI：
10.1056/nejmoa0905498
发表时间：
2009-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cauchemez S;Donnelly CA;Reed C;Ghani AC;Fraser C;Kent CK;Finelli L;Ferguson NM
通讯作者：
Ferguson NM
影响因子：
3.7
作者：
Higuera Iglesias AL;Kudo K;Manabe T;Corcho Berdugo AE;Corrales Baeza A;Alfaro Ramos L;Guevara Gutiérrez R;Manjarrez Zavala ME;Takasaki J;Izumi S;Bautista E;Perez Padilla JR
通讯作者：
Perez Padilla JR
影响因子：
3.7
作者：
Chuang JH;Huang AS;Huang WT;Liu MT;Chou JH;Chang FY;Chiu WT
通讯作者：
Chiu WT
影响因子：
11.8
作者：
Leo YS;Lye DC;Barkham T;Krishnan P;Seow E;Chow A
通讯作者：
Chow A