meiRNA, A Polyvalent Player in Fission Yeast Meiosis
meiRNA, A Polyvalent Player in Fission Yeast Meiosis
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DOI：
10.3390/ncrna5030045
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发表时间：
2019-09
期刊：
影响因子：
4.3
通讯作者：
A. Yamashita
中科院分区：
文献类型：
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作者：
A. Yamashita
近年来越来越多的研究表明，非编码RNA发挥着超出预期的广泛作用。许多非编码RNA已被证明通过在细胞核或细胞质中形成细胞内结构来发挥功能。在裂殖酵母裂殖酵母中，一种称为meiRNA的非编码RNA已被证明在减数分裂过程中发挥多种重要作用。meiRNA在转录后被拴在其遗传位点上，并形成独特的核内点结构。它与RNA结合蛋白Mei2合作确保减数分裂基因的稳定表达。染色体相关的meiRNA还促进同源染色体基因座的识别并诱导稳健的配对。在这篇综述中，四分之一世纪的历史，从它的识别到功能表征，将被概述。
A growing number of recent studies have revealed that non-coding RNAs play a wide variety of roles beyond expectation. A lot of non-coding RNAs have been shown to function by forming intracellular structures either in the nucleus or the cytoplasm. In the fission yeast Schizosaccharomyces pombe, a non-coding RNA termed meiRNA has been shown to play multiple vital roles in the course of meiosis. meiRNA is tethered to its genetic locus after transcription and forms a peculiar intranuclear dot structure. It ensures stable expression of meiotic genes in cooperation with an RNA-binding protein Mei2. Chromosome-associated meiRNA also facilitates recognition of homologous chromosome loci and induces robust pairing. In this review, the quarter-century history of meiRNA, from its identification to functional characterization, will be outlined.