The QUALYOR (QUalite Osseuse LYon Orleans) study: a new cohort for non invasive evaluation of bone quality in postmenopausal osteoporosis. Rationale and study design
The QUALYOR (QUalite Osseuse LYon Orleans) study: a new cohort for non invasive evaluation of bone quality in postmenopausal osteoporosis. Rationale and study design
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DOI：
10.1007/s11657-017-0412-6
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发表时间：
2017-12-27
影响因子：
3
通讯作者：
Lespessailles, Eric
中科院分区：
文献类型：
--
作者：
Chapurlat, Roland;Pialat, Jean-Baptiste;Lespessailles, Eric
光密度测定的诊断性能是不够的。骨质量非侵入性评估的新技术可能会改善骨折风险预测。测试这些技术的价值是QUALIOR cohol.IntroductionThe绝经后妇女的骨矿物质密度（BMD）维持骨质疏松性骨折的目标是普遍高于世界卫生组织定义的骨质疏松症。因此，新的方法，以提高妇女在骨折的高风险检测是warranty.MethodsWe设计和招募了一个新的队列，以评估几种技术来评估骨质量的预测价值，包括高分辨率外周定量计算机断层扫描（HRpQCT），髋关节QCT，跟骨纹理分析，和生化标志物。我们招募了1575名绝经后妇女，年龄至少50岁，股骨颈或腰椎BMD T评分在-1.0和-3.0之间。骨折的临床危险因素已收集沿着与血清和血液samples.ResultsWe描述的设计的QUADOR研究。在这1 575名妇女中，80%的年龄至少为60岁。平均股骨颈T评分为-1.6，平均腰椎T评分为-1.2。这一队列目前正在跟进。ConclusionsQUALGOOR将提供重要的信息，骨质量变量和骨折风险之间的关系，在妇女中度降低BMD。
A SummaryThe diagnostic performance of densitometry is inadequate. New techniques of non-invasive evaluation of bone quality may improve fracture risk prediction. Testing the value of these techniques is the goal of the QUALYOR cohort.IntroductionThe bone mineral density (BMD) of postmenopausal women who sustain osteoporotic fracture is generally above the World Health Organization definition for osteoporosis. Therefore, new approaches to improve the detection of women at high risk for fracture are warranted.MethodsWe have designed and recruited a new cohort to assess the predictive value of several techniques to assess bone quality, including high-resolution peripheral quantitative computerized tomography (HRpQCT), hip QCT, calcaneus texture analysis, and biochemical markers. We have enrolled 1575 postmenopausal women, aged at least 50, with an areal BMD femoral neck or lumbar spine T-score between - 1.0 and - 3.0. Clinical risk factors for fracture have been collected along with serum and blood samples.ResultsWe describe the design of the QUALYOR study. Among these 1575 women, 80% were aged at least 60. The mean femoral neck T-score was - 1.6 and the mean lumbar spine T-score was -1.2. This cohort is currently being followed up.ConclusionsQUALYOR will provide important information on the relationship between bone quality variables and fracture risk in women with moderately decreased BMD.