DISSOCIATION OF SYMPATHETIC-NERVE ACTIVITY IN ARM AND LEG MUSCLE DURING MENTAL STRESS
DISSOCIATION OF SYMPATHETIC-NERVE ACTIVITY IN ARM AND LEG MUSCLE DURING MENTAL STRESS
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DOI：
10.1161/01.hyp.9.6_pt_2.iii114
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发表时间：
1987-06-01
期刊：
影响因子：
8.3
通讯作者：
MARK, AL
中科院分区：
文献类型：
--
作者：
ANDERSON, EA;WALLIN, BG;MARK, AL
精神压力会增加血压和心率，增加前臂的血流量，但不会改变小腿的血流量。这项研究的目的是确定精神压力是否会增加腿部肌肉交感神经的活动，并导致手臂和腿部肌肉交感神经活动的分离。我们记录了13名健康男性在精神压力（4分钟心算）期间的心率、血压和传出交感神经活动。微电极经皮插入腓神经束（腿）和桡神经束（臂）来测量交感神经对肌肉的放电。在研究1中，记录了7名受试者的腿部肌肉交感神经活动。精神压力会显著增加心率和血压。尽管血压升高（预期会反射性地抑制交感神经活动），腿部肌肉交感神经活动（总的综合活动，每100次心跳或每分钟爆发）在压力下显著增加。此外，虽然心率和血压在康复期间恢复正常，但腿部肌肉交感神经活动在康复期间仍然升高。在研究2中，对6名受试者的手臂和腿部肌肉交感神经活动进行同步记录。精神压力会增加心率和动脉压。腿部肌肉交感神经活动在压力下再次显著增加，并在恢复期间保持升高。相反，手臂肌肉交感神经活动在压力下没有变化。然而，手臂肌肉交感神经活动在应激后恢复期间显著增加。这些研究表明，精神压力的交感兴奋影响超过或抑制腿部交感神经活动的压力感受器控制，压力导致手臂和腿部肌肉交感神经活动分离，增加流向腿部而不是流向手臂。这些观察结果可能会导致在精神压力下流向手臂和腿部的血流量的差异。
Mental stress, which increases blood pressure and heart rate, increases forearm blood flow but does not change calf blood flow. The purpose of this study was to determine if mental stress increases muscle sympathetic nerve activity in the leg and causes a dissociation of muscle sympathetic nerve activity in the arm and the leg. We recorded heart rate, blood pressure, and efferent sympathetic nerve activity during mental stress (4 minutes of mental arithmetic) in 13 healthy men. Microelectrodes were inserted percutaneously into a fascicle of the peroneal nerve (leg) and radial nerve (arm) to measure sympathetic discharge to muscle. In Study 1, leg muscle sympathetic nerve activity was recorded in seven subjects. Mental stress significantly increased heart rate and blood pressure. Despite the increased blood pressure (which would be expected reflexly to inhibit sympathetic nerve activity), leg muscle sympathetic nerve activity (in total integrated activity, bursts per 100 heart beats or bursts per minute) increased significantly during stress. Further, whereas heart rate and blood pressure returned to normal during recovery, leg muscle sympathetic nerve activity remained elevated during recovery. In Study 2, simultaneous recordings were made of arm and leg muscle sympathetic nerve activity in six subjects. Mental stress increased heart rate and arterial pressure. Leg muscle sympathetic nerve activity again increased significantly during stress and remained elevated during recovery. In contrast, arm muscle sympathetic nerve activity did not change during stress. However, arm muscle sympathetic nerve activity increased significantly during recovery after stress. These studies indicate that a sympathoexcitatory influence of mental stress overrides or inhibits baroreceptor control of leg sympathetic nerve activity and stress causes a dissociation of arm and leg muscle sympathetic nerve activity with increased outflow to the leg but not to the arm. These observations may contribute to differences in blood flow to arm and leg during mental stress.