Cranial sutures and bones: Growth and fusion in relation to masticatory strain
Cranial sutures and bones: Growth and fusion in relation to masticatory strain
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DOI：
10.1002/ar.a.20002
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发表时间：
2004-02-01
期刊：
影响因子：
--
通讯作者：
Herring, SW
中科院分区：
文献类型：
--
作者：
Sun, ZY;Lee, E;Herring, SW
在咀嚼过程中，颅骨和缝合线是机械加载的。然而，他们对咀嚼劳损的反应在很大程度上是未知的，特别是在年龄变化的背景下。本研究利用应变片对3月龄和7月龄小型猪(Sus Scrofa)的后额间缝、前顶间缝及其邻近骨骼的咀嚼应变进行了研究。对这些动物和另外一个5个月组的动物进行双荧光标记，以显示缝合和骨生长以及缝合形态和融合的特征。随着年龄的增长，后额间缝应变逐渐减小，由单纯压缩向压缩和拉伸并存，而顶间缝合在未融合线的情况下仍处于张力状态，且张力增大。在形态上，3个月大的猪额间后缝高度错位，然后在颅外失去错位，而顶间前缝保持对接。矿化沉积率(MAR)随年龄增长而降低，与应变无关。额骨和顶骨外颅面的骨矿化最为活跃。与缝线不同的是，随着年龄的增长，骨应变保持不变，而骨MARS显著增加，并与骨厚度相关。部分猪的顶缝发生融合。在所有病例中，融合都是外颅融合，而不是内颅融合。融合似乎与骨缝张力增加和外颅骨表面骨生长增强有关。综上所述，这些结果表明年龄是颅骨应变和生长的一个重要因素。(C)2004年Wiley-Liss公司
Cranial bones and sutures are mechanically loaded during mastication. Their response to masticatory strain, however, is largely unknown, especially in the context of age change. Using strain gages, this study investigated masticatory strain in the posterior interfrontal and the anterior interparietal sutures and their adjacent bones in 3- and 7-month-old miniature swine (Sus scrofa). Double-fluorochrome labeling of these animals and an additional 5-month group was used to reveal suture and bone growth as well as features of suture morphology and fusion. With increasing age, the posterior interfrontal suture strain decreased in magnitude and changed in pattern from pure compression to both compression and tension, whereas the interparietal suture remained in tension and the magnitude increased unless the suture was fused. Morphologically, the posterior interfrontal suture was highly interdigitated at 3 months and then lost interdigitation ectocranially in older pigs, whereas the anterior interparietal suture remained butt-ended. Mineralization apposition rate (MAR) decreased with age in both sutures and was unrelated to strain. Bone mineralization was most vigorous on the ectocranial surface of the frontal and the parietal bones. Unlike the sutures, with age bone strain remained constant while bone MARs significantly increased and were correlated with bone thickness. Fusion had occurred in the interparietal suture of some pigs. In all cases fusion was ectocranial rather than endocranial. Fusion appeared to be associated with increased suture strain and enhanced bone growth on the ectocranial surface. Collectively, these results indicate that age is an important factor for strain and growth of the cranium. (C) 2004 Wiley-Liss, Inc.