A controlled trial of timed bright light and negative air ionization for treatment of winter depression
A controlled trial of timed bright light and negative air ionization for treatment of winter depression
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DOI：
10.1001/archpsyc.55.10.875
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发表时间：
1998-10-01
影响因子：
--
通讯作者：
Ross, DC
中科院分区：
文献类型：
--
作者：
Terman, M;Terman, JS;Ross, DC
背景：人造亮光为季节性情感障碍提供了一种有前景的非药物治疗方法。然而，过去的研究缺乏足够的安慰剂对照或足够的能力来检测群体差异。一天中治疗时间的重要性（特别是晨光优势）仍然存在争议。 方法：本研究使用早晨 X 晚上光交叉设计，通过平行组对照进行平衡，此外还采用非光控制、负空气电离。患有季节性情感障碍的受试者 (N = 158) 被随机分配到 6 组，接受 2 个连续治疗期，每组 10 至 14 天。光处理顺序为早上-晚上、晚上-早上、早上-早上和晚上-晚上（10000勒克斯，30分钟/天）。离子密度为每立方厘米 2.7 X 10(6)（高）或 1.0 X 10(4)（低）离子（高-高和低-低顺序，早上 30 分钟/天）。结果：抑郁量表百分比变化分数分析显示，低密度离子反应劣于所有其他组，没有其他组差异。在晨光（唯一的序列效应）治疗之前，对傍晚光的反应会减弱。然而，无论治疗顺序如何，严格的缓解标准显示，对早晨光的反应明显高于晚上。结论：明亮的光和高密度空气负电离似乎都可以作为季节性情感障碍患者的特异性抗抑郁药。联合使用它们或作为药物的佐剂是否会进一步增强临床改善，还有待研究。
Background: Artificial bright light presents a promising nonpharmacological treatment for seasonal affective disorder. Past studies, however, have lacked adequate:placebo controls or sufficient power to detect group differences. The importance of time of day of treatment-specifically, morning light superiority-has remained controversial.Methods: This study used a morning X evening light crossover design balanced by parallel-group controls, in addition to a nonphotic control, negative air ionization. Subjects with seasonal affective disorder (N = 158) were randomly assigned to 6 groups for 2 consecutive treatment periods, each 10 to 14 days. Light treatment sequences were morning-evening, evening-morning, morning-morning and evening-evening (10 000 lux, 30 min/d). Ion density was 2.7 X 10(6) (high) or 1.0 X 10(4) (low) ions per cubic centimeter (high-high and low-low sequences, 30 min/d in the morning).Results: Analysis of depression scale percentage change scores showed low-density ion response to be inferior to all other groups, with no other group differences. Response to evening light was reduced when preceded by treatment with morning light, the sole sequence effect. Stringent remission criteria, however, showed significantly higher response to morning than evening light, regardless of treatment sequence.Conclusions: Bright light and high-density negative air ionization both appear to act as specific antidepressants in patients with seasonal affective disorder. Whether clinical improvement would be further enhanced by their use in combination, or as adjuvants to medication, awaits investigation.