From the authors
From the authors
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DOI：
10.1183/09031936.00114607
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发表时间：
2008-01
影响因子：
24.3
通讯作者：
Saad Nseir
中科院分区：
文献类型：
--
作者：
Saad Nseir
我们要感谢P. Frost和M.P. Wise的评论，并希望对他们提出的一些问题作出回应。牙菌斑、口咽腔和胃是危重患者微生物的潜在储存库。吸入污染的口咽和胃分泌物在需要通过气管内插管或气管切开插管进行机械通气的重症监护室（ICU）患者中很常见1。呼吸机相关性肺炎（VAP）最重要的机制是口咽部微生物大量或微量吸入远端支气管，随后细菌增殖和实质侵入，导致支气管肺炎。
We would like to thank P. Frost and M.P. Wise for their comments, and wish to respond to some of the points they raised. Dental plaque, the oropharyngeal cavity and the stomach are potential reservoirs for microorganisms in critically ill patients. Aspiration of contaminated oropharyngeal and gastric secretions is common in intensive care unit (ICU) patients requiring mechanical ventilation through an endotracheal tube or a tracheotomy cannula 1. The most important mechanism of ventilator-associated pneumonia (VAP) is gross or micro-aspiration of oropharyngeal microorganisms into the distal bronchi, followed by bacterial proliferation and parenchymal invasion, leading to bronchopneumonia …