Chronic intracranial recordings after resection for epilepsy reveal a "running down" of epileptiform activity.
Chronic intracranial recordings after resection for epilepsy reveal a "running down" of epileptiform activity.
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癫痫切除后的慢性颅内记录显示癫痫样活动“减弱”。
DOI：
10.1111/epi.17645
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发表时间：
2023
期刊：
影响因子：
5.6
通讯作者：
Rolston,JohnD
中科院分区：
文献类型：
--
作者：
Kundu,Bornali;Charlebois,ChantelM;Anderson,DariaNesterovich;Peters,Angela;Rolston,JohnD
我们描述了一种电“运行”现象，也是一个一致的频谱变化（在功率谱的非周期性组成部分）来自慢性发作间期皮层脑电图（ECoG）手术后的耐药性癫痫患者。使用切除后植入的闭环神经刺激系统记录这些数据。自切除术以来，患者已无癫痫发作2.5年，无需打开神经刺激器进行刺激。同时，该装置记录的癫痫样电描记检测次数呈指数下降，特别是在前26周内，表明随着大脑适应延长的无癫痫发作期，出现了电耗尽现象。我们还发现，随着时间的推移，功率谱的非周期指数逐渐减少。颅内ECoG的非周期性成分可能代表了一种新的致痫性标志物，独立于癫痫发作。
We describe an electrical "running down" phenomenon and also a consistent spectral change (in the aperiodic component of the power spectrum) derived from chronic interictal electrocorticography (ECoG) after surgery in a patient with drug‐resistant epilepsy. These data were recorded using a closed‐loop neurostimulation system that was implanted after resection. The patient has been seizure‐free for 2.5 years since resection without requiring the neurostimulator to be turned on to stimulate. Concurrently, there was an exponential decrease in the number of epileptiform electrographic detections recorded by the device, particularly over the first 26 weeks, indicative of an electrical running down phenomenon as the brain adapted to an extended period of seizure freedom. We also find that the aperiodic exponent of the power spectrum gradually decreases over time. The aperiodic component of intracranial ECoG may represent a novel marker of epileptogenicity, independent of seizures.