Absorption and metabolism of genistin in the isolated rat small intestine
Absorption and metabolism of genistin in the isolated rat small intestine
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DOI：
10.1016/s0014-5793(00)01642-2
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发表时间：
2000-06-16
期刊：
影响因子：
3.5
通讯作者：
Fürst, P
中科院分区：
文献类型：
--
作者：
Andlauer, W;Kolb, J;Fürst, P
在离体肠灌注模型中研究了生理活性染料木苷的摄取和肠代谢;管腔应用浓度为5.9、12.0和23.8 μ mol/L。染料木苷的肠吸收率为14.9%（+/- 2.3，n = 9），与施用量无关。大部分吸收的染料木黄酮以染料木黄酮葡萄糖醛酸苷（11.6%）的形式出现，也以管腔侧的主要代谢产物（19.5%）的形式回收。在血管侧发现少量的染料木黄酮（1.3%）和染料木黄酮（1.9%），而15.4%的染料木黄酮被腔内裂解产生染料木黄酮，未观察到染料木黄酮或染料木黄酮的硫酸盐衍生物。(C)2000欧洲生物化学学会联合会，由Elsevier Science B. V.出版，版权所有。
Uptake and intestinal metabolism of physiologically active genistin were studied in an ex vivo intestinal perfusion model; luminally applied concentrations were 5.9, 12.0, and 23.8 mu mol/l. The intestinal absorption of genistin was 14.9% (+/- 2.3, n = 9), irrespective of the amounts applied. The majority of the absorbed genistin appeared as genistein glucuronide (11.6%), also recovered as the main metabolite on the luminal side (19.5%). Minor amounts of genistin (1.3%) and genistein (1.9%) were found on the vascular side, whereas 15.4% of applied genistin was luminally cleaved to yield genistein, Sulfate derivatives of genistein or genistin were not observed. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.