First-trimester C-roactive protein and subsequent gestational diabetes
First-trimester C-roactive protein and subsequent gestational diabetes
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DOI：
10.2337/diacare.26.3.819
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发表时间：
2003-03-01
期刊：
影响因子：
16.2
通讯作者：
Thadhani, R
中科院分区：
文献类型：
--
作者：
Wolf, M;Sandler, L;Thadhani, R
客观-全身炎症与 2 型糖尿病的发生有关。我们测试了这样的假设：妊娠早期测量到的炎症增加与妊娠糖尿病 (GDM)（2 型糖尿病的前兆）的后续发展相关。研究设计和方法 - 我们在妊娠队列中进行了一项前瞻性巢式病例对照研究。使用高分辨率测定法测量了 43 名随后患 GDM 的女性以及随机抽取的 94 名在整个怀孕期间血糖保持正常的女性的妊娠早期 C 反应蛋白 (CRP) 水平。使用 Wilcoxon 的秩和检验比较中位 CRP 水平。 Logistic 回归用于计算 CRP 三分位数中发生 GDM 的未调整和多变量调整比值比。 结果 - 与对照受试者相比，随后发生 GDM 的女性的妊娠早期 CRP 水平显着升高（3.1 与 2.1 mg/l，P
Objective-Systemic inflammation is associated with the development of type 2 diabetes. We tested the hypothesis that increased inflammation, measured early in pregnancy, is associated with the subsequent development of gestational diabetes mellitus (GDM), a precursor of type 2 diabetes.Research Design and Methods-We conducted a prospective nested case-control study in a pregnancy cohort. First-trimester C-reactive protein (CRP) levels were measured using a high-resolution assay in 43 women who subsequently developed GDM and in a random sample of 94 women who remained euglycemic throughout pregnancy. Median CRP levels were compared using Wilcoxon's rank-sum test. Logistic regression was used to compute unadjusted and multivariable-adjusted odds ratios for developing GDM among CRP tertiles.Results-First-trimester CRP levels were significantly increased among women who subsequently developed GDM compared with control subjects (3.1 vs. 2.1 mg/l, P