Circadian Misalignment Impacts the Association of Visceral Adiposity With Elevated Blood Pressure in Adolescents.
Circadian Misalignment Impacts the Association of Visceral Adiposity With Elevated Blood Pressure in Adolescents.
复制标题
昼夜节律失调影响青少年内脏肥胖与血压升高的关系。
DOI：
10.1161/hypertensionaha.122.20398
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Fernandez-Mendoza,Julio
中科院分区：
文献类型：
--
作者：
Morales-Ghinaglia,Natasha;Larsen,Michael;He,Fan;Calhoun,SusanL;Vgontzas,AlexandrosN;Liao,Jason;Liao,Duanping;Bixler,EdwardO;Fernandez-Mendoza,Julio
研究背景虽然睡眠不足已被证明与肥胖相关的血压升高有关，但睡眠的昼夜节律已成为一个新的风险因素。我们假设，偏差的睡眠中点，昼夜节律的睡眠时间的措施，修改内脏肥胖和血压升高的青少年之间的关联。MethodsWe研究了303例受试者从宾夕法尼亚州立大学儿童队列（16.2±2.2岁，47.5%的女性，21.5%的种族/少数民族）。活动描记法测量的睡眠持续时间，中点，变异性和规律性计算了7个晚上的时间。采用双能X线吸收法测量内脏脂肪组织（VAT）。在坐姿下测量收缩压（SBP）和舒张压水平。多变量线性回归模型测试了睡眠中点及其规律性作为VAT对SBP/舒张压水平的影响修饰因子，同时调整了人口统计学和睡眠协变量。这些协会也被检查作为一个功能是在学校或on-break. ResultsVAT和睡眠不规律，但不是睡眠中点，收缩压（Pinteraction=0.007）和舒张压（Pinteraction=0.022）之间的显着相互作用。此外，VAT和学生日睡眠中点对SBP有显著的交互作用（P相互作用=0.026）和舒张压（P交互作用=0.043），而VAT与工作日休息时睡眠不规律对SBP有显著交互作用（Pinteraction=0.034）.结论在学校和自由活动期间，睡眠中点延迟和不规则，增加增值税对青少年血压升高的影响。这些数据表明，在昼夜节律的睡眠时间的偏差有助于增加与肥胖相关的心血管后遗症，其独特的指标需要在不同的夹带条件下测量青少年。
BackgroundAlthough insufficient sleep has been shown to contribute to obesity-related elevated blood pressure, the circadian timing of sleep has emerged as a novel risk factor. We hypothesized that deviations in sleep midpoint, a measure of circadian timing of sleep, modify the association between visceral adiposity and elevated blood pressure in adolescents.MethodsWe studied 303 subjects from the Penn State Child Cohort (16.2±2.2 years; 47.5% female; 21.5% racial/ethnic minority). Actigraphy-measured sleep duration, midpoint, variability, and regularity were calculated across a 7-night period. Visceral adipose tissue (VAT) was measured with dual-energy X-ray absorptiometry. Systolic blood pressure (SBP) and diastolic blood pressure levels were measured in the seated position. Multivariable linear regression models tested sleep midpoint and its regularity as effect modifiers of VAT on SBP/diastolic blood pressure levels, while adjusting for demographic and sleep covariables. These associations were also examined as a function of being in-school or on-break.ResultsSignificant interactions were found between VAT and sleep irregularity, but not sleep midpoint, on SBP (Pinteraction=0.007) and diastolic blood pressure (Pinteraction=0.022). Additionally, significant interactions were found between VAT and schooldays sleep midpoint on SBP (Pinteraction=0.026) and diastolic blood pressure (Pinteraction=0.043), whereas significant interactions were found between VAT and on-break weekdays sleep irregularity on SBP (Pinteraction=0.034).ConclusionsA delayed and an irregular sleep midpoint during school and during free-days, respectively, increase the impact of VAT on elevated blood pressure in adolescents. These data suggest that deviations in the circadian timing of sleep contribute to the increased cardiovascular sequelae associated with obesity and that its distinct metrics require measurement under different entrainment conditions in adolescents.