Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
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DOI：
10.1038/nn1270
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发表时间：
2004-07-01
影响因子：
25
通讯作者：
Choquet, D
中科院分区：
文献类型：
--
作者：
Groc, L;Heine, M;Choquet, D
AMPA受体（AMPAR）和NMDA受体（NMDAR）的活性依赖性运输差异的基础尚不清楚。使用单分子跟踪，我们发现不同的横向迁移率为AMPAR和NMDAR：神经元活动的变化修改AMPAR，但不NMDAR的流动性，而蛋白激酶C激活修改两者。迁移率的差异主要检测到突触外AMPAR，表明突触和突触外域之间的受体扩散参与可塑性过程。
The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.