Birth Weight in Relation to Leisure Time Physical Activity in Adolescence and Adulthood: Meta-Analysis of Results from 13 Nordic Cohorts
Birth Weight in Relation to Leisure Time Physical Activity in Adolescence and Adulthood: Meta-Analysis of Results from 13 Nordic Cohorts
复制标题
DOI：
10.1371/journal.pone.0008192
复制
发表时间：
2009-12-16
期刊：
影响因子：
3.7
通讯作者：
Baker, Jennifer L.
中科院分区：
文献类型：
--
作者：
Andersen, Lise Geisler;Angquist, Lars;Baker, Jennifer L.
背景：产前暴露，潜在地表现为出生大小的改变，可能通过对疾病过程的直接生物影响，但也通过改变成年人的行为，如可能影响未来疾病风险的体育活动，来影响主要慢性病的未来风险。方法/主要发现：我们调查了来自13个北欧队列的43,482名青少年和成年人的出生体重与休闲时间体力活动(LTPA)之间的关系。随机效应荟萃分析是对来自队列、年龄、性别和出生体重特定分析的分类估计进行的。出生体重与后来的LTPA呈倒U型相关；在正常体重范围内，这种关联可以忽略不计，但体重低于或高于这一范围与进行LTPA的可能性较低相关。出生体重1.26~1.75、1.76~2.25、2.26~2.75、4.76~5.25 kg与参考体重(3.26~3.75 kg)相比，优势比分别为0.67(95%可信区间：0.47、0.94)、0.72(0.59、0.88)、0.89(0.79、0.99)、0.65(0.50、0.86)。出生体重与LTPA关联的形式和强度几乎与性别、年龄、胎龄、教育程度、同时体重指数和吸烟无关。结论/意义：在正常出生体重范围内，出生体重与LTPA之间的关联很弱，但低出生体重和高出生体重都与患LTPA的概率较低相关，因此这可能是产前影响和以后疾病风险之间的中介因素。
Background: Prenatal life exposures, potentially manifested as altered birth size, may influence the later risk of major chronic diseases through direct biologic effects on disease processes, but also by modifying adult behaviors such as physical activity that may influence later disease risk.Methods/Principal Findings: We investigated the association between birth weight and leisure time physical activity (LTPA) in 43,482 adolescents and adults from 13 Nordic cohorts. Random effects meta-analyses were performed on categorical estimates from cohort-, age-, sex- and birth weight specific analyses. Birth weight showed a reverse U-shaped association with later LTPA; within the range of normal weight the association was negligible but weights below and above this range were associated with a lower probability of undertaking LTPA. Compared with the reference category (3.26-3.75 kg), the birth weight categories of 1.26-1.75, 1.76-2.25, 2.26-2.75, and 4.76-5.25 kg, had odds ratios of 0.67 (95% confidence interval: 0.47, 0.94), 0.72 (0.59, 0.88), 0.89 (0.79, 0.99), and 0.65 (0.50, 0.86), respectively. The shape and strength of the birth weight-LTPA association was virtually independent of sex, age, gestational age, educational level, concurrent body mass index, and smoking.Conclusions/Significance: The association between birth weight and undertaking LTPA is very weak within the normal birth weight range, but both low and high birth weights are associated with a lower probability of undertaking LTPA, which hence may be a mediator between prenatal influences and later disease risk.