STRESS-INDUCED CHANGES IN INTESTINAL TRANSIT IN THE RAT - A MODEL FOR IRRITABLE BOWEL SYNDROME
STRESS-INDUCED CHANGES IN INTESTINAL TRANSIT IN THE RAT - A MODEL FOR IRRITABLE BOWEL SYNDROME
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DOI：
10.1016/0016-5085(88)90231-4
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发表时间：
1988-03-01
期刊：
影响因子：
29.4
通讯作者：
BURKS, TF
中科院分区：
文献类型：
--
作者：
WILLIAMS, CL;VILLAR, RG;BURKS, TF
在人类中，应激通常会导致胃肠功能障碍，其症状特点是病因完全未知。我们开发了一个动物模型来研究应激对胃肠道的影响，并通过评估内分泌和对轻度束缚的止痛反应来将该模型描述为应激源。轻度束缚(包裹束缚)可提高血浆促肾上腺皮质激素和β-内啡肽水平，并引起镇痛。胃肠道的不同区域对应激刺激的反应不同。应激对胃排空无影响，对小肠转运有抑制作用，对大肠转运有刺激作用，粪便排泄增加。包扎应激不会导致溃疡的形成。在24小时内，应激诱导的促肾上腺皮质激素释放和应激诱导的肠道功能障碍之间有很强的相关性，这表明了昼夜节律的影响。然而，外源性促肾上腺皮质激素和β-内啡肽对肠道转运均无影响。此外，肾上腺切除或脑垂体切除都不能阻止肠道对应激的反应，这表明肾上腺和脑下垂体衍生的因子都不能调节应激对肠道的影响。我们得出结论，束缚应激对肠道不同区域产生不同的影响，表明小肠和大肠是独立调节的，对不同刺激的反应不同。束缚应激对大鼠的肠道效应与应激相关的肠道症状和应激影响肠道转运的肠易激综合征有相似之处；然而，应激的肠道效应不是由垂体或肾上腺来源的因子介导的。
Stress in humans commonly results in gastrointestinal dysfunction, which is characterized by its symptomatology because the etiology is completely unknown. We developed an animal model in which to study the effects of stress on the gastrointestinal tract, and characterized the model as a stressor by evaluating endocrine and analgesic responses to mild restraint. Mild restraint (wrap restraint) elevated plasma levels of adrenocorticotropic hormone and .beta.-endorphin, and caused analgesia. The different regions of the gastrointestinal tract responded differently to the stress stimulus. Gastric emptying was not affected, small intestinal transit was inhibited, and large intestinal transit was stimulated by stress, and there was an associated increase in fecal excretion. Wrap-restraint stress did not result in the formation of ulcers. There was a strong correlation between stress-induced adrenocorticotropic hormone release and stress-induced intestinal dysfunction over a 24-h period that suggested a circadian influence. However, neither exogenous adrenocorticotropic hormone nor .beta.-endorphin had any effect on intestinal transit. Furthermore, neither adrenalectomy nor hypophysectomy prevented the response of the intestine to stress, suggesting that neither adrenal nor pituitary-derived factors are responsible for mediating the effects of stress on the gut. We conclude that wrap-restraint stress produces different effects on different regions of the intestine, suggesting that the small and large intestines are independently regulated and can respond differently to different stimuli. There were similarities between the intestinal effects of wrap-restraint stress in rats and intestinal symptoms associated with stress and irritable bowel syndrome which stress affects intestinal transit are still unresolved; however, the intestinal effects of stress are not mediated by either pituitary or adrenally derived factors.