DISTINCTIVE FEATURES OF THE 5'-TERMINAL SEQUENCES OF THE HUMAN MITOCHONDRIAL MESSENGER-RNAS
DISTINCTIVE FEATURES OF THE 5'-TERMINAL SEQUENCES OF THE HUMAN MITOCHONDRIAL MESSENGER-RNAS
复制标题
DOI：
10.1038/290465a0
复制
发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
ATTARDI, G
中科院分区：
文献类型：
--
作者：
MONTOYA, J;OJALA, D;ATTARDI, G
测定HeLa细胞线粒体DNA重链编码的所有推定mRNA的5”端近端序列，并与DNA序列对齐。除了从AUU开始的mRNA外，所有这些mRNA都直接或非常接近于AUG或AUA三联体。现有证据表明，末端或亚末端的AUG和AUA，也可能是末端的AUU，是相应多肽的启动密码子。在大多数情况下，单个mRNA编码序列在其5'侧由tRNA基因连接，没有任何中间核苷酸。
The 5''-end proximal sequences of all the putative mRNA coded for by the heavy strand of HeLa cell mitochondrial DNA were determined and aligned with the DNA sequence. All these mRNA start directly at, or very near to, an AUG or AUA triplet, with the exception of one which starts at an AUU. The available evidence indicates that the terminal or subterminal AUG and AUA, and possibly also the terminal AUU, are initiator codons for the corresponding polypeptides. In most cases, the individual mRNA coding sequences are flanked on their 5'' side by a tRNA gene, without any intervening nucleotide.