FACTORS DETERMINING DIRECT ARTERIAL-PRESSURE AND ITS VARIABILITY IN HYPERTENSIVE MAN
FACTORS DETERMINING DIRECT ARTERIAL-PRESSURE AND ITS VARIABILITY IN HYPERTENSIVE MAN
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DOI：
10.1161/01.hyp.2.3.333
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发表时间：
1980-01-01
期刊：
影响因子：
8.3
通讯作者：
LITTLER, WA
中科院分区：
文献类型：
--
作者：
WATSON, RDS;STALLARD, TJ;LITTLER, WA
在标准化条件下连续记录26例无并发症原发性高血压患者的动脉内压。逐搏分析记录，以获得平均压力和变异性，表示为频率直方图的标准差。影响变异性的主要因素是压力水平和体力活动强度;收缩期变异性随着窦主动脉压力反射的进行性损害而增加。血浆去甲肾上腺素水平反映了舒张压随交感神经活动水平的增加而增加。允许血浆肾素活性（PRA）随年龄的下降后，PRA（对数值）和压力水平和收缩期变异性之间观察到直接关系;血浆血管紧张素II值没有相关性。收缩期变异性随着对冷的收缩反应而增加，但与对动态或等长运动的反应无关。变异性也倾向于随着肥胖而增加，与年龄、性别或种族无关。
Intra-arterial pressure was recorded continuously in 26 patients with uncomplicated essential hypertension under standardized conditions. Recordings were analyzed beat by beat to obtain mean pressures and variability, expressed as the standard deviation of the frequency histogram. The major factors influencing variability were the level of pressure and the intensity of physical activity; systolic variability increased with progressive impairment of sino-aortic baroreflexes. Diastolic pressure increased with the level of sympathetic activity as reflected by plasma norepinephrine levels. After allowance for the decrease of plasma renin activity (PRA) with age, direct relationships were observed between PRA (log values) and the level of pressure and systolic variability; plasma angiotensin II values did not correlate. Systolic variability increased with the systolic response to cold but was unrelated to the response to dynamic or isometric exercise. Variability also tended to increase with obesity and was unrelated to age, sex or race.