Shaping Up Mitochondria in Diabetic Nephropathy.
Shaping Up Mitochondria in Diabetic Nephropathy.
复制标题
糖尿病肾病中线粒体的形成。
DOI：
10.34067/kid.0002352020
复制
发表时间：
2020-09-24
期刊：
影响因子：
--
通讯作者：
Danesh FR
中科院分区：
文献类型：
--
作者：
Mise K;Galvan DL;Danesh FR
Mitochondrial medicine has experienced significant progress in recent years and is expected to grow significantly in the near future, yielding many opportunities to translate novel bench discoveries into clinical medicine. Multiple lines of evidence have linked mitochondrial dysfunction to a variety of metabolic diseases, including diabetic nephropathy (DN). Mitochondrial dysfunction presumably precedes the emergence of key histologic and biochemical features of DN, which provides the rationale to explore mitochondrial fitness as a novel therapeutic target in patients with DN. Ultimately, the success of mitochondrial medicine is dependent on a better understanding of the underlying biology of mitochondrial fitness and function. To this end, recent advances in mitochondrial biology have led to new understandings of the potential effect of mitochondrial dysfunction in a myriad of human pathologies. We have proposed that molecular mechanisms that modulate mitochondrial dynamics contribute to the alterations of mitochondrial fitness and progression of DN. In this comprehensive review, we highlight the possible effects of mitochondrial dysfunction in DN, with the hope that targeting specific mitochondrial signaling pathways may lead to the development of new drugs that mitigate DN progression. We will outline potential tools to improve mitochondrial fitness in DN as a novel therapeutic strategy. These emerging views suggest that the modulation of mitochondrial fitness could serve as a key target in ameliorating progression of kidney disease in patients with diabetes.
登录
查看更多内容
影响因子：
5.5
作者：
Abe, Yoshifusa;Sakairi, Toru;Kopp, Jeffrey B.
通讯作者：
Kopp, Jeffrey B.
影响因子：
13.6
作者：
Ayanga, Bernard A.;Badal, Shawn S.;Danesh, Farhad R.
通讯作者：
Danesh, Farhad R.
影响因子：
4.8
作者：
Eid, Assaad A.;Ford, Bridget M.;Abboud, Hanna E.
通讯作者：
Abboud, Hanna E.
影响因子：
4.6
作者：
Escribano-Lopez I;Diaz-Morales N;Iannantuoni F;Lopez-Domenech S;de Marañon AM;Abad-Jimenez Z;Bañuls C;Rovira-Llopis S;Herance JR;Rocha M;Victor VM
通讯作者：
Victor VM
影响因子：
13.6
作者：
Coughlan, Melinda T.;Thorburn, David R.;Forbes, Josephine M.
通讯作者：
Forbes, Josephine M.