Dexamethasone attenuates lipopolysaccharide‐induced liver injury by downregulating glucocorticoid‐induced tumor necrosis factor receptor ligand in Kupffer cells
Dexamethasone attenuates lipopolysaccharide‐induced liver injury by downregulating glucocorticoid‐induced tumor necrosis factor receptor ligand in Kupffer cells
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DOI：
10.1111/j.1872-034x.2011.00852.x
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发表时间：
2011-10
影响因子：
4.2
通讯作者：
Si-dong Wei;Jin Li;Zuo-jin Liu;Qi Chen;Yong Chen;Min Chen;J. Gong
中科院分区：
文献类型：
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作者：
Si-dong Wei;Jin Li;Zuo-jin Liu;Qi Chen;Yong Chen;Min Chen;J. Gong
目的：糖皮质激素诱导的肿瘤坏死因子受体配体（GITRL）在免疫应答中起促炎作用。因此，我们的目的是评估地塞米松是否通过影响枯否细胞（KC）中的GITRL来减轻脂多糖（LPS）诱导的肝损伤。
Aim: Glucocorticoid‐induced tumor necrosis factor receptor ligand (GITRL) plays pro‐inflammatory roles in immune response. Thus, our aim was to assess if dexamethasone attenuates lipopolysaccharide (LPS)‐induced liver injury by affecting GITRL in Kupffer cells (KC).