Hyperpolarisation-activated current in glomerular cells of the rat olfactory bulb
Hyperpolarisation-activated current in glomerular cells of the rat olfactory bulb
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DOI：
10.1097/00001756-200110080-00027
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发表时间：
2001-10-08
期刊：
影响因子：
1.7
通讯作者：
Belluzzi, O
中科院分区：
文献类型：
--
作者：
Cadetti, L;Belluzzi, O
全细胞膜片钳记录进行了视觉识别的肾小球周围和外部簇状细胞的大鼠嗅球。大多数的神经元表现出一个缓慢发展的超极化激活电流的阈值一般为正的静息电位和强烈的电压依赖性激活时间常数。电流，确定为I-H，是钠和钾敏感，抑制外部铯，钡不敏感。在电流钳条件下，灌注铯引起10 mV的超极化和实验诱导的低频振荡率显着降低。它的结论是，在大鼠肾小球层的细胞中的大多数提出了一个独特的h-电流，这是紧张性活跃在休息，这可能有助于延髓网络的振荡行为。NeuroReport 12：3117-3120（C）2001 Lippincott威廉姆斯和威尔金斯。
Whole-cell patch-clamp recordings were carried out in visually identified periglomerular and external tufted cells of rat olfactory bulb. Most of the neurones showed a slowly developing hyperpolarisation-activated current with a threshold generally positive to resting potential and with a strongly voltage-dependent activation time constant. The current, identified as I-h, was sodium- and potassium-sensitive, suppressed by external caesium, and insensitive to barium. Under current-clamp conditions, perfusion with caesium induced a 10 mV hyperpolarisation and a marked reduction of the rate of low-frequency oscillations induced experimentally. It is concluded that most of the cells in the rat glomerular layer present a distinct h-current, which is tonically active at rest and which may contribute to the oscillatory behaviour of the bulbar network. NeuroReport 12:3117-3120 (C) 2001 Lippincott Williams & Wilkins.