Multiple Adjoining Word- and Face-Selective Regions in Ventral Temporal Cortex Exhibit Distinct Dynamics
Multiple Adjoining Word- and Face-Selective Regions in Ventral Temporal Cortex Exhibit Distinct Dynamics
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DOI：
10.1523/jneurosci.3234-20.2021
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发表时间：
2021-07-21
影响因子：
5.3
通讯作者：
Ghuman, Avniel Singh
中科院分区：
文献类型：
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作者：
Boring, Matthew J.;Silson, Edward H.;Ghuman, Avniel Singh
人类腹侧颞叶皮层（VTC）的类别选择性图谱为物体识别模型提供了组织约束。一个重要的原则是外侧-内侧反应偏向于通常在视野的中心或外围看到的刺激。然而，对于优先响应集中观看的刺激类别的区域的相对时间动态和位置知之甚少，例如面部和文字处理网络。在这里，使用来自36名患者的颅内记录来绘制VTC内的单词和面部选择区域。在VTC中发现了部分重叠，但在解剖学上可分离的面孔和单词选择性斑块。除了沿左侧后枕颞沟的规范词选择区域外，选择性也位于梭状回的内侧和前部的面部选择区域，在群体水平和个体男性和女性受试者中。这些区域被健康人用7特斯拉fMRI复制。左半球单词选择区域比右半球反应早125 ms，可能反映了左半球对语言的偏好，而在面部选择反应延迟上没有半球差异。单词选择区沿着后梭状回首先反应，然后向内侧和外侧扩散，然后向前。面部选择反应首先出现在双侧的后梭状回区域，然后从那里开始向前发展。对于文字和面孔，区域之间的相对延迟比单纯的视觉处理前馈模型所预测的要长。这些区域和大脑半球之间反应的不同时间过程表明，一个复杂而动态的功能回路支持着面部和文字感知。
The map of category-selectivity in human ventral temporal cortex (VTC) provides organizational constraints to models of object recognition. One important principle is lateral-medial response biases to stimuli that are typically viewed in the center or periphery of the visual field. However, little is known about the relative temporal dynamics and location of regions that respond preferentially to stimulus classes that are centrally viewed, such as the face-and word-processing networks. Here, word-and face-selective regions within VTC were mapped using intracranial recordings from 36 patients. Partially overlapping, but also anatomically dissociable patches of face-and word-selectivity, were found in VTC. In addition to canonical word-selective regions along the left posterior occipitotemporal sulcus, selectivity was also located medial and anterior to face-selective regions on the fusiform gyrus at the group level and within individual male and female subjects. These regions were replicated using 7 Tesla fMRI in healthy subjects. Left hemisphere word-selective regions preceded right hemisphere responses by 125 ms, potentially reflecting the left hemisphere bias for language, with no hemispheric difference in face -selective response latency. Word-selective regions along the posterior fusiform responded first, then spread medially and laterally, then anteriorally. Face-selective responses were first seen in posterior fusiform regions bilaterally, then proceeded anteriorally from there. For both words and faces, the relative delay between regions was longer than would be predicted by purely feed forward models of visual processing. The distinct time courses of responses across these regions, and between hemispheres, suggest that a complex and dynamic functional circuit supports face and word perception.