Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite
Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite
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DOI：
10.1016/j.biomaterials.2003.10.016
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发表时间：
2004-08-01
期刊：
影响因子：
14
通讯作者：
Ramakrishna, S
中科院分区：
文献类型：
--
作者：
Murugan, R;Ramakrishna, S
本研究旨在开发用于骨修复和再生的生物可吸收复合材料。尽管纳米羟基磷灰石(HA)具有广泛的医学应用，但其颗粒动员和缓慢的可吸收特性限制了其在某些应用中的应用，特别是在牙周和牙槽骨隆起方面。为了提高其实用性，我们以天然多糖壳聚糖为原料，在低温下采用湿化学法制备了HA复合骨浆。用不同的物理化学方法对所制备的复合材料进行了分析，结果表明纳米HA微晶与壳聚糖大分子保持着良好的完整性。FT-IR结果表明，除了纳米HA的特征峰外，复合糊料中还存在羟基和酰胺基。膏体形态的物理性质表明，它将非常有利于植入后的颗粒固定。在生理条件下，对复合材料在磷酸盐缓冲盐水中的体外生理稳定性和溶解性进行了研究，发现复合材料的吸收率远高于纳米HA。这些发现表明，HA/壳聚糖复合材料作为可生物吸收的骨替代材料，可能会对人类健康保健系统产生重大影响。(C)2003爱思唯尔有限公司。保留所有权利。
Aim of this study concerns to the development of bioresorbable composite materials for bone repair and regeneration. Despite nano hydroxyapatite (HA) has wide range of medical applications, particles mobilization and slow resorbable nature limits its use in certain applications particularly, periodontal and alveolar ridge augmentation. To enhance its usage, we have prepared HA composite bone paste with a natural polysaccharide, chitosan, using wet chemical method at low temperature. The prepared composites were analyzed by various physicochemical methods and suggesting that the nano HA crystallites are well intact with the chitosan macromolecules. FT-IR results are indicating the existence of hydroxyl and amide groups in addition to the characteristic peaks of nano HA in the composite paste. The physical nature of paste form implies that it would be highly beneficial for the particle immobilization upon implantation. In vitro physiological stability and solubility of the composite was performed in phosphate buffered saline under physiological condition and found that the rate of resorbability of composite was quite higher than nano HA. These findings suggest that the HA/chitosan composites may have a great impact on human health care systems as bioresorbable bone substitute. (C) 2003 Elsevier Ltd. All rights reserved.