High prevalence of hepatitis markers in immigrant populations: a prospective screening approach in a real-world setting
High prevalence of hepatitis markers in immigrant populations: a prospective screening approach in a real-world setting
复制标题
DOI：
10.1097/meg.0000000000000164
复制
发表时间：
2014-10-01
影响因子：
2.1
通讯作者：
Bastuerk, Murat
中科院分区：
文献类型：
--
作者：
Heidrich, Benjamin;Cetindere, Ahmet;Bastuerk, Murat
背景移民人群被认为感染肝炎病毒的频率更高。然而，在学术中心之外，关于移民的数据是有限的、公正的。因此，这项研究的目的是在初级保健中心进行大规模的肝炎标志物筛查，主要针对具有德国移民背景的个人。方法2010年11月至2012年1月，我们在德国西北部的8个初级保健中心前瞻性地筛查了1313名由全科医生治疗的患者。如果患者或他们的父母不是在德国出生的，他们就有资格。对每个个体进行了乙肝核心蛋白抗体、乙肝表面抗原和抗丙型肝炎病毒抗体的血清学筛查。对HBs Ag阳性和抗-C病毒阳性患者进一步检测病毒复制的分子标志物。在患者中，45.7%是男性；87.3%从东地中海地区移民到德国，12.0%来自东欧。在这些患者中，32.5%的患者乙肝核心蛋白抗体检测呈阳性。3.6%的患者检测到了乙肝表面抗原。总体而言，在2.2%的患者中检测到了乙肝病毒DNA。丙型肝炎病毒感染标志物的出现频率几乎相同(1.9%)。有流动背景的人对一般传播途径的知识明显缺乏。结论与德国一般人群相比，外来人口中肝炎病毒感染的发病率确实更高。这些数据强调了在这一特殊风险群体中引入筛查计划的重要性。(C)2014沃尔特斯·克鲁沃健康折断竖杆Lippincott Williams&Wilkins。
Background Immigrant populations are believed to be more frequently infected with hepatitis viruses. However, limited unbiased data are available on immigrants outside of academic centres. Therefore, the aim of this study was to perform large-scale screening for hepatitis markers in primary care centres treating mainly individuals with a migrational background in Germany.Methods Between November 2010 and January 2012, we prospectively screened 1313 individuals treated by general practitioners at eight primary care centres in North-western Germany. Patients were eligible if they or their parents were not born in Germany. Serological screening for hepatitis B core protein antibodies, hepatitis B surface antigens (HBsAgs), and anti-hepatitis C virus antibodies was performed in each individual. HBsAg-positive and anti-hepatitis C virus-positive patients were further tested for molecular markers of viral replication.Results The mean age was 49.1 +/- 15.8 years. Of the patients, 45.7% were male; 87.3% had migrated to Germany from the Eastern Mediterranean area and 12.0% from Eastern Europe. Of the patients, 32.5% tested positive for hepatitis B core protein antibodies. HBsAgs were found in 3.6% of patients. Overall, hepatitis B virus DNA was detected in 2.2% of patients. Markers for hepatitis C virus infection were found in an almost similar high frequency (1.9%). Individuals with migrational background showed significant deficits in knowledge on general routes of transmission.Conclusion Hepatitis virus infections are indeed significantly more prevalent in immigrant populations as compared with the general German population. These data underline the importance of introducing screening programs in this particular risk group. (C) 2014 Wolters Kluwer Health broken vertical bar Lippincott Williams & Wilkins.