Activation of RNA polymerase II transcription
Activation of RNA polymerase II transcription
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DOI：
10.1016/s0955-0674(99)80045-3
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发表时间：
1999-06-01
影响因子：
7.5
通讯作者：
Berk, AJ
中科院分区：
文献类型：
--
作者：
Berk, AJ
多个替代之间的相互作用-激活子和辅激活子刺激RNA聚合酶II的转录。在过去的两年中，多蛋白共激活复合物的特点和它们的亚基定义。酵母TFIID的TATA盒结合蛋白相关因子（TAF）亚基被发现是体内转录所必需的。哺乳动物多亚基辅激活因子复合物与同源的酵母SRB/介体亚基的特点。核受体-辅激活因子复合物的结构已被确定。
Multiple alternative interactions between-activators and coactivators stimulate transcription by RNA poymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription in vivo. Mammalian multisubunit coactivator complexes with homologs of the yeast SRB/Mediator subunits have been characterized. Structures of nuclear receptor-coactivator complexes have been determined.