Distribution and metabolism of trans- and cis-permethrin in lactating Jersey cows.
Distribution and metabolism of trans- and cis-permethrin in lactating Jersey cows.
复制标题
反式和顺式氯菊酯在泌乳泽西奶牛中的分布和代谢。
DOI：
10.1021/jf60217a003
复制
发表时间：
1978
影响因子：
6.1
通讯作者：
J. Casida
中科院分区：
文献类型：
--
作者：
L. C. Gaughan;M. Ackerman;T. Unai;J. Casida
从~4C-酸和~(14)C-乙醇标记的反式和顺式氯氰菊酯制剂中提取的放射性碳，以1.0 mg/kg连续三天口服给哺乳的泽西奶牛，在最初治疗后的12或13天内大部分从体内清除。牛奶和脂肪残留量虽然相对较低，但使用顺式氯氰菊酯的牛奶和脂肪残留量高于使用反式氯氰菊酯的牛奶和脂肪残留量，并且几乎全部由未代谢的化合物组成。顺式氯氰菊酯在甲基上羟基化为酯官能团，也存在于牛奶中的痕量水平。两种异构体排出的主要代谢物(分别为8-2870个给药放射性碳)是：在反式甲基上羟化的酯；在顺式甲基和相应的γ-内酯之间羟基化的酸性部分；3-苯氧基苯甲醇；3-苯氧基苯甲酸的谷氨酸偶合物。初步鉴定了13种反式氯菊酯和10种顺式氯菊酯的代谢物。
Radiocarbon from I4C-acidand 14C-alcohol-labeled preparations of transand cis-permethrin administered orally to lactating Jersey cows for three consecutive days at 1.0 mg/kg is largely eliminated from the body within 12 or 13 days after the initial treatment. Milk and fat residues, although relatively low, are higher with cisthan with trans-permethrin and consist almost entirely of unmetabolized compound. cis-Permethrin hydroxylated at the methyl group trans to the ester functionality also appears in trace levels in milk. Major excreted metabolites (each 8-2870 of the administered radiocarbon) from both isomers are: the esters hydroxylated at the trans methyl group; the acid moieties hydroxylated a t the cis methyl group and the corresponding y-lactones; 3-phenoxybenzyl alcohol; the glutamic acid conjugate of 3-phenoxybenzoic acid. An additional 13 excreted metabolites of trans-permethrin and 10 of cis-permethrin are tentatively identified.