Expression of the orexigenic peptide ghrelin in the sheep ovary
Expression of the orexigenic peptide ghrelin in the sheep ovary
复制标题
促食欲肽生长素释放肽在绵羊卵巢中的表达
DOI：
10.1016/j.domaniend.2008.10.007
复制
发表时间：
2009-02-01
影响因子：
2.1
通讯作者：
Cao, Jinshan
中科院分区：
文献类型：
--
作者：
Du, Chenguang;Xi lingaowa;Cao, Jinshan
Ghrelin与生殖组织中细胞增殖的控制有关。在这里，我们提供的证据表明，饥饿素mRNA和蛋白质都存在于卵巢卵泡。在整个发情周期和妊娠期，ghrelin也在绵羊卵巢中持续表达。事实上，生长激素释放肽的相对mRNA水平因周期阶段而异，在黄体（CL）发育期间表达最高，而在退行性CL中表达最低。怀孕期间也出现了类似的情况。在动情周期和整个妊娠期间生长激素释放肽表达的动态变化表明卵巢生长激素释放肽表达的精确调节，这可能代表生长激素释放肽在调节黄体发育中的潜在作用。总之，羊卵巢内，特别是在卵母细胞的胃饥饿素信号系统的存在开辟了一个潜在的调节作用，这种新的分子在生殖功能的可能性。(C)2008年爱思唯尔公司All rights reserved.
Ghrelin has been implicated in the control of cell proliferation in reproductive tissue. Here, we provide evidence that both ghrelin mRNA and protein are present in ovarian follicles. Persistent expression of ghrelin was also demonstrated in sheep ovary throughout the estrous cycle and pregnancy. In fact, the relative mRNA levels of ghrelin varied depending on the stage of the cycle, with the highest expression during the development of the corpora lutea (CL) and minimal expression in the regressing CL. A similar pattern was seen during pregnancy. Dynamic changes in the profile of ghrelin expression during the estrous cycle and throughout pregnancy suggest a precise regulation of ovarian expression of ghrelin, which could represent a potential role for ghrelin in the regulation of luteal development. In conclusion, the presence of the ghrelin signaling system within the sheep ovary especially in the oocytes opens up the possibility of a potential regulatory role of this novel molecule in reproductive function. (C) 2008 Elsevier Inc. All rights reserved.