Early inflammatory changes in the "perilesional skin" of psoriatic plaques: Is there interaction between dendritic cells and keratinocytes?
Early inflammatory changes in the "perilesional skin" of psoriatic plaques: Is there interaction between dendritic cells and keratinocytes?
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DOI：
10.1038/sj.jid.5700799
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发表时间：
2007-08-01
影响因子：
6.5
通讯作者：
Tamaki, Kunihiko
中科院分区：
文献类型：
--
作者：
Komine, Mayumi;Karakawa, Masaru;Tamaki, Kunihiko
通过研究银屑病患者斑块附近的正常外观皮肤（病变周围皮肤）、病变皮肤和远处未受累皮肤，以化学方法研究银屑病斑块的早期炎症变化。皮损周围表皮含有大量CD 1a阳性朗格汉斯细胞，其中一些表达HLA-DR、CD 83、CD 80和CD 86，同时表达Langerin。皮损周围皮肤表皮-真皮交界处也有大量CD 83阳性、CD 11 c阳性、Langerin阴性的树突状细胞（DCs）。CD 3阳性T淋巴细胞在病灶周围皮肤稀疏。皮损周围表皮表达角蛋白K6和K16、炎性角蛋白和C/EBP β（一种与炎性细胞因子相关的转录因子）。我们的研究结果表明，在银屑病斑块的皮损周围皮肤中，在表皮角质形成细胞中发生早期炎症变化，这表明它们参与了皮损周围表皮中表皮炎症的激发，并在银屑病斑块的形成中发挥进一步的致病作用。
Early inflammatory changes in psoriatic plaques were investigated immunohistochemically by studying the normal-appearing skin adjacent to the plaques (perilesional skin), lesional skin, and distant uninvolved skin from psoriasis patients. Perilesional epidermis contained numerous CD1a-positive Langerhans cells, some of which expressed HLA-DR, CD83, CD80, and CD86, at the same time expressing Langerin. There were also numerous CD83-positive, CD11c-positive, Langerin-negative clendritic cells (DCs) in the epidermal-dermal junction of perilesional skin. CD3-positive T lymphocytes were sparse in the perilesional skin. Perilesional epidermis expressed keratin K6 and K16, inflammatory keratins, and C/EBP beta, a transcription factor related to inflammatory cytokines. Our results demonstrated the abundant distribution of activated DCs in the perilesional skin of psoriatic plaques, where early inflammatory changes occur in the epidermal keratinocytes, which suggests their involvement in the provocation of epidermal inflammation in the perilesional epidermis and further pathogenic roles in the formation of psoriatic plaques.