Reduction of β-hydroxyketones by Sml2/H2O/Et3N
Reduction of β-hydroxyketones by Sml2/H2O/Et3N
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DOI：
10.1021/ol047835p
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发表时间：
2005-01-06
期刊：
影响因子：
5.2
通讯作者：
Flowers, RA
中科院分区：
文献类型：
--
作者：
Davis, TA;Chopade, PR;Flowers, RA
用SmI2/H2O/Et3N还原一系列β -羟基酮，定量产率为1,3-二醇。反应非常干净，没有产生副产物，不需要进一步净化。在大多数情况下，以正二醇为主要异构体的反应具有中等至优异的非对映选择性。
Reduction of a series of beta-hydroxyketones by SmI2/H2O/Et3N provided 1,3-diols in quantitative yields. The reactions were exceedingly clean with no byproduct formation, negating the need for further purification. Most reactions provided moderate to excellent diastereoselectivity with syn-diols as the major isomer in most instances.