OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study.
OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study.
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DOI：
10.1167/iovs.16-20976
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发表时间：
2017-07-01
影响因子：
4.4
通讯作者：
Ehlers JP
中科院分区：
文献类型：
--
作者：
Runkle AP;Kaiser PK;Srivastava SK;Schachat AP;Reese JL;Ehlers JP
评价黄斑毛细血管扩张症2型（MacTel 2型）患者光学相干断层扫描血管造影（OCT-A）的改变，并定量评估椭圆体区（EZ）的改变。在视网膜疾病中使用光学相干断层扫描血管造影术可视化和分析血管的观察性评估研究是一项机构审查委员会批准的前瞻性观察性研究，旨在研究黄斑疾病中的OCT-A。患者在单次访视时接受了频域（SD）-OCT和OCT-A成像。使用新型OCT EZ映射软件分析SD-OCT数据，以获得横跨黄斑立方体的EZ-视网膜色素上皮（RPE）复合体的线性、面积和体积测量值。使用Optovue Avanti分裂谱振幅去相关血管造影算法测量OCT-A视网膜毛细血管密度。将EZ-RPE参数与年龄匹配、性别匹配的对照进行比较。分析了7名患者（平均年龄59 ± 6.5岁）的14只眼睛。平均视力为20/45（范围：20/20-20/150）。EZ-RPE中央凹平均厚度为27.8 ± 6.7 μm，EZ-RPE中央凹厚度为22.1 ± 21.6 μm，EZ-RPE中央凹面积为0.17 ± 0.04 mm 2，EZ-RPE中央子区域体积为0.017 ± 0.012 mm 3。各项指标与视力呈显著负相关（P < 0.02）。此外，与对照组相比，所有这些测量值均显著降低（所有P ≤ 0.005）。OCT-A显示，在浅表血管丛中，颞侧和鼻侧血管密度分别为50.8%和53.8%（P = 0.01）。在深部血管丛中，也观察到类似的发现，颞侧中央窝旁血管密度为56.7%，鼻侧为58.8%（P = 0.01）。EZ-RPE厚度、面积和体积的减少与MacTel 2型的视力相关，并且可以提供定量标记来测量疾病进展和治疗反应。OCT-A是确定疾病严重程度的有用辅助手段。
To evaluate alterations on optical coherence tomography angiography (OCT-A) and quantitatively assess alterations in the ellipsoid zone (EZ) in eyes with macular telangiectasia type 2 (MacTel type 2). The Observational Assessment of Visualizing and Analyzing Vessels With Optical Coherence Tomography Angiography in Retinal Diseases study is an institutional review board-approved prospective, observational study investigating OCT-A in macular disease. Patients underwent spectral-domain (SD)-OCT and OCT-A imaging at a single visit. SD-OCT data were analyzed using a novel OCT EZ-mapping software to obtain linear, area, and volumetric measurements of the EZ-retinal pigment epithelium (RPE) complex across the macular cube. OCT-A retinal capillary density was measured using the Optovue Avanti split-spectrum amplitude-decorrelation angiography algorithm. EZ-RPE parameters were compared to age-matched, sex-matched controls. Fourteen eyes of seven patients (mean age, 59 ± 6.5 years) were analyzed. Mean visual acuity was 20/45 (range, 20/20–20/150). EZ-RPE central foveal mean thickness was 27.8 ± 6.7 μm, EZ-RPE central foveal thickness was 22.1 ± 21.6 μm, EZ-RPE central foveal area was 0.17 ± 0.04 mm2, and EZ-RPE central subfield volume was 0.017 ± 0.012 mm3. Each of these measurements was significantly inversely correlated with visual acuity (P < 0.02). In addition, all of these measurements were significantly reduced compared to controls (all P ≤ 0.005). OCT-A showed a reduced parafoveal vessel density of 50.8% temporally compared to 53.8% nasally (P = 0.01) in the superficial vascular plexus. In the deep vascular plexus, similar findings were noted with a parafoveal vessel density of 56.7% temporally and 58.8% nasally (P = 0.01). Abnormalities in EZ-RPE thickness, area, and volume are correlated with visual acuity in MacTel type 2, and may provide quantitative markers to measure disease progression and treatment response. OCT-A was a useful adjunct for determining disease severity.