DNA mismatch repair proteins: potential guardians against genomic instability and tumorigenesis induced by ultraviolet photoproducts.
DNA mismatch repair proteins: potential guardians against genomic instability and tumorigenesis induced by ultraviolet photoproducts.
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DOI：
10.1046/j.1523-1747.2003.12450.x
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发表时间：
2003-09
期刊：
影响因子：
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通讯作者：
L. C. Young;J. Hays;V. Tron;S. Andrew
中科院分区：
文献类型：
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作者：
L. C. Young;J. Hays;V. Tron;S. Andrew
除了它们在修复复制后DNA错误中的既定作用之外，DNA错配修复蛋白响应于广泛的外源DNA损伤（例如，烷基化诱导的损伤）。DNA错配修复在紫外线诱导的DNA损伤中的作用历来存在争议。然而，最近的数据表明，DNA错配修复蛋白可能不会有助于去除紫外线诱导的DNA损伤，但可能是重要的抑制诱变，影响细胞凋亡，并抑制肿瘤发生后暴露于紫外线辐射。
In addition to their established role in repairing post-replicative DNA errors, DNA mismatch repair proteins contribute to cell cycle arrest and apoptosis in response to a wide range of exogenous DNA damage (e.g., alkylation-induced lesions). The role of DNA mismatch repair in response to ultraviolet-induced DNA damage has been historically controversial. Recent data, however, suggest that DNA mismatch repair proteins probably do not contribute to the removal of ultraviolet-induced DNA damage, but may be important in suppressing mutagenesis, effecting apoptosis, and suppressing tumorigenesis following exposure to ultraviolet radiation.