The predominant site of pharyngeal lesions in patients with recurrent respiratory papillomatosis
The predominant site of pharyngeal lesions in patients with recurrent respiratory papillomatosis
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DOI：
10.1007/s00405-022-07407-6
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发表时间：
2022-05-03
影响因子：
2.6
通讯作者：
Makiyama，Kiyoshi
中科院分区：
文献类型：
--
作者：
Matsuzaki，Hiroumi;Asai，Ryohei;Makiyama，Kiyoshi
目的复发性呼吸道乳头状瘤病（RRP）是一种以呼吸道良性肿瘤经常复发为特征的疾病。有些RRP患者发展为喉乳头状瘤，而另一些患者则表现为鼻、咽和气管的喉外病变。本研究的目的是确定咽部的位置，其中RRP-related病变的发展更frequent.MethodsWe回顾性分析了127例患者在我科治疗的医疗记录2015年1月至2020年12月。我们比较了41例RRP和86例咽乳头状瘤（PP）患者的人乳头状瘤病毒（HPV）感染状况和肿瘤位置的差异。结果在RRP组中，10例患者中观察到喉外乳头状瘤，其中8例（19.5%）出现在鼻咽下壁（IWoN）病变。相反，只有1例PP（1.1%）在该区域发生乳头状瘤。IWoN乳头状瘤是更有可能出现在RRP组比PP group.ConclusionIn RRP，咽部病变经常出现在IWoN，而该地区在很大程度上保持不受影响的PP患者。
PurposeRecurrent respiratory papillomatosis (RRP) is a disorder characterized by the frequent recurrence of benign neoplasms in the respiratory tract. Some patients with RRP develop laryngeal papilloma, while others present with extralaryngeal lesions in the nose, pharynx, and trachea. The present study aimed to determine the pharyngeal sites where RRP-related lesions develop more frequently.MethodsWe retrospectively reviewed the medical records of 127 patients treated at our department between January 2015 and December 2020. We compared the human papilloma virus (HPV) infection status and differences in tumor location between 41 patients with RRP and 86 patients with pharyngeal papilloma (PP).ResultsIn the RRP group, extralaryngeal papillomata were observed in 10 patients, eight (19.5%) of whom presented with lesions in the inferior wall of the nasopharynx (IWoN). On the contrary, only one patient with PP (1.1%) developed papillomata in this region. IWoN papilloma was significantly more likely to arise in the RRP group than in the PP group (p= 0.0004).ConclusionIn RRP, pharyngeal lesions frequently arise in the IWoN, while this region remains largely unaffected in patients with PP.