6-Hydroxydopamine-Induced Dopamine Reductions in the Nucleus Accumbens, but not the Medial Prefrontal Cortex, Impair Cincinnati Water Maze Egocentric and Morris Water Maze Allocentric Navigation in Male Sprague-Dawley Rats
6-Hydroxydopamine-Induced Dopamine Reductions in the Nucleus Accumbens, but not the Medial Prefrontal Cortex, Impair Cincinnati Water Maze Egocentric and Morris Water Maze Allocentric Navigation in Male Sprague-Dawley Rats
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DOI：
10.1007/s12640-016-9616-6
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发表时间：
2016-08-01
影响因子：
3.7
通讯作者：
Williams, Michael T.
中科院分区：
文献类型：
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作者：
Braun, Amanda A.;Amos-Kroohs, Robyn M.;Williams, Michael T.
伏隔核(NACC)和内侧前额叶皮质(MPFC)接受腹侧被盖区的多巴胺能神经支配，参与学习。对6-羟基多巴胺(6-OHDA)诱导的NACC或mPFC多巴胺能和去甲肾上腺素能减少的雄性大鼠进行了分配中心学习和自我中心学习，以确定它们在这些形式的神经可塑性中的作用。MPFC多巴胺和去甲肾上腺素能减少并未导致学习或记忆类型的改变。在获得、翻转和探测实验中，NACC多巴胺和去甲肾上腺素能减少导致Morris水迷宫(MWM)的异位学习和记忆障碍。MWM提示性能也受到影响，但MWM中隐藏平台试验期间的直道游泳时间和游泳速度不受影响。在辛辛那提水迷宫(CWM)中，NACC多巴胺能和去甲肾上腺素能的减少也损害了以自我为中心的学习。在CWM中测试的NACC损伤动物在迷宫中的另一条路径上没有受到明显影响。在NACC注射6-OHDA后，NACC的多巴胺和去甲肾上腺素分别减少了63%和62%，邻近的背侧纹状体减少了23%。在mPFC注射6-OHDA后，多巴胺减少了88%，去甲肾上腺素减少了59%。因此，NACC多巴胺和/或去甲肾上腺素在以自我为中心和以分配为中心的学习和记忆中发挥作用，而mPFC多巴胺和去甲肾上腺素则不起作用。
The nucleus accumbens (Nacc) and medial prefrontal cortex (mPFC) receive dopaminergic innervation from the ventral tegmental area and are involved in learning. Male rats with 6-hydroxydopamine (6-OHDA)-induced dopaminergic and noradrenergic reductions in the Nacc or mPFC were tested for allocentric and egocentric learning to determine their role in these forms of neuroplasticity. mPFC dopaminergic and noradrenergic reductions did not result in changes to either type of learning or memory. Nacc dopaminergic and noradrenergic reductions resulted in allocentric learning and memory deficits in the Morris water maze (MWM) on acquisition, reversal, and probe trials. MWM cued performance was also affected, but straight-channel swim times and swim speed during hidden platform trials in the MWM were not affected. Nacc dopaminergic and noradrenergic reductions also impaired egocentric learning in the Cincinnati water maze (CWM). Nacc-lesioned animals tested in the CWM in an alternate path through the maze were not significantly affected. 6-OHDA injections in the Nacc resulted in 63 % dopamine and 62 % norepinephrine reductions in the Nacc and 23 % reductions in adjacent dorsal striatum. 6-OHDA injections in the mPFC resulted in 88 % reductions in dopamine and 59 % reductions in norepinephrine. Hence, Nacc dopamine and/or norepinephrine play a role in egocentric and allocentric learning and memory, while mPFC dopamine and norepinephrine do not.