Persistent silver disinfectant for the environmental control of pathogenic bacteria
Persistent silver disinfectant for the environmental control of pathogenic bacteria
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DOI：
10.1067/mic.2003.23
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发表时间：
2003-06-01
影响因子：
4.9
通讯作者：
Sawan, SP
中科院分区：
文献类型：
--
作者：
Brady, MJ;Lisay, CM;Sawan, SP
背景：受污染的表面可能会成为病原微生物的储存库，并有可能加剧感染的风险。表面消毒和去污可暂时改善细菌定植情况。消毒后的表面最终会受到污染，从而降低了最初消毒的益处。假设为了改善目前的技术状态，消毒剂不仅应该立即对表面进行消毒，而且应该在产品应用后提供持久的抗菌作用。我们描述了一种银基消毒剂技术，旨在为处理过的表面提供持久的卫生和消毒，在反复环境污染后对处理过的表面进行评估。方法：对6种消毒剂配方进行水冲洗后残留抗菌活性的比较评价。在接触消毒剂30分钟至8小时后，测量经消毒剂处理的基质上细菌数量的对数减少，并与未处理的对照组进行比较。在一项类似的研究中，还评估了一种银消毒剂在水冲洗后对抗生素和杀菌剂抗药性细菌的残留抗菌活性。进一步，对具有代表性的家居和医院内致病菌(大肠埃希菌、金黄色葡萄球菌、肺炎克雷伯菌、产气肠杆菌、粪肠球菌、猪霍乱沙门氏菌)，经5次漂洗、磨损和污染10分钟后，检测其对S的残留抗菌活性。结果，在比较测定中，只有银消毒剂和一种持久性季铵复合消毒剂对S金黄色葡萄球菌有显著的残留活性(大于或等于3.0log(10)减少量以控制)。没有观察到其他消毒剂产品的残留活性(小于或等于未经处理的对照的对数减少0.5log)。这种以银为基础的消毒剂对抗生素和抗银细菌也显示出显著和同等的效果。此外，银消毒剂能够在10分钟内对所有被测试的微生物在1、3和5次水洗、磨损和微生物污染后获得显著的残留活性。结论：研究结果表明，一种新的银基消毒剂能够在几分钟内减少接触处理表面的细菌数量，突出阻止环境表面交叉污染的潜力，并降低家庭和卫生保健环境中的感染风险。
Background, Contaminated surfaces can act as a reservoir for pathogenic microorganisms and potentially exacerbate the risk of infection. Surface disinfection and decontamination provide temporary amelioration against bacterial colonization. Disinfected surfaces eventually become contaminated, thus, mitigating the benefit of the initial disinfection. It is hypothesized that to improve on the current state of the art, a disinfectant should not only immediately disinfect a surface but also provide persistent antimicrobial action after the product has been applied. We describe here a silver-based disinfectant technology designed to provide long-lasting sanitization and disinfection to treated surfaces as evaluated on hard surfaces after repeated environmental insults.Methods: A comparative evaluation of 6 disinfectant formulations for residual antimicrobial activity after water rinsing was performed. Log reduction of bacterial populations on disinfectant-treated substrates were measured after 30 minutes to 8 hours of exposure and compared with an untreated control. In a similar study the residual antimicrobial activity of a silver disinfectant was evaluated against antibiotic- and biocide-resistant bacteria also after water rinsing. Further, residual antimicrobial activity of the silver disinfectant was measured after 5 cycles of rinsing, abrasion, and contamination against representative household and nosocomial pathogens (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Enterobacter aerogenes, Enterococcus faecium, or Salmonella choleraesuis) after 10-minute exposure times.Results: In the comparative assay, only the silver disinfectant and a persistent quaternary ammonium compound disinfectant demonstrated significant residual activity (greater than or equal to 3.0 log(10) reduction to control) against S aureus whereas only the silver disinfectant demonstrated activity against Pseudomonas. No residual activity (less than or equal to 0.5 log reduction to untreated control) was observed for the other disinfectant products. The silver-based disinfectant also showed significant and equivalent efficacy against antibiotic- and silver-resistant bacteria. In addition, the silver disinfectant was able to achieve significant residual activity in 10 minutes against all organisms tested after 1, 3, and 5 cycles of water rinse, abrasion, and microbial contamination.Conclusions: The findings show the ability of a new silver-based disinfectant to reduce bacterial populations that contact treated surfaces within minutes, highlight the potential to interrupt cross-contamination from environmental surfaces, and reduce the risk of infection within the home and health care settings.