Identification of clinical predictors of diabetic nephropathy and non-diabetic renal disease in Chinese patients with type 2 diabetes, with reference to disease course and outcome
Identification of clinical predictors of diabetic nephropathy and non-diabetic renal disease in Chinese patients with type 2 diabetes, with reference to disease course and outcome
复制标题
参考病程和结果，识别中国 2 型糖尿病患者糖尿病肾病和非糖尿病肾病的临床预测因子。
DOI：
10.1007/s00592-019-01324-7
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发表时间：
2019-08-01
影响因子：
3.8
通讯作者：
Liu, Fang
中科院分区：
文献类型：
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作者：
Wang, Jiali;Han, Qianqian;Liu, Fang
目的 确定 2 型糖尿病 (T2DM) 患者中糖尿病肾病 (DN) 和非糖尿病肾病 (NDRD) 的患病率，以及肾脏结局和临床病程的重要临床预测因素。 方法我们对经肾活检证实有肾脏受累的 T2DM 患者 (n=505) 的临床、实验室和组织病理学数据进行回顾性分析。结果定义为进展为终末期肾病 (ESRD)。 结果肾活检显示 302 名患者 (59.8%) 患有 DN，174 名患者 (34.5%) 患有 NDRD，29 名患者 (5.7%) NDRD 叠加在 DN 上。在多变量分析中，不存在糖尿病视网膜病变（DR）（比值比（OR）4.171，95%置信区间（CI）1.810-9.612；P=0.001），不存在高血压（OR 2.412，95% CI 1.095-5.315；P=0.029），糖尿病病程较短（OR 1.015， 95% CI 1.008-1.022；P
AimsTo determine the prevalence of diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) in patients with type 2 diabetes mellitus (T2DM), and the important clinical predictors of renal outcome and clinical course.MethodsWe conducted a retrospective analysis of clinical, laboratory, and histopathologic data from T2DM patients with renal involvement confirmed by renal biopsy (n=505). The outcome was defined as the progression to end-stage renal disease (ESRD).ResultsRenal biopsy revealed that 302 patients (59.8%) had DN, 174 (34.5%) had NDRD, and 29 (5.7%) had NDRD superimposed on DN. In multivariate analysis, the absence of diabetic retinopathy (DR) (odds ratio (OR) 4.171, 95% confidence interval (CI) 1.810-9.612; P=0.001), absence of hypertension (OR 2.412, 95% CI 1.095-5.315; P=0.029), shorter duration of diabetes (OR 1.015, 95% CI 1.008-1.022; P