One versus two biological parents with mental disorders: Relationship to educational attainment in the next generation.
One versus two biological parents with mental disorders: Relationship to educational attainment in the next generation.
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DOI：
10.1017/s0033291722003506
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发表时间：
2023-11
影响因子：
6.9
通讯作者：
Nordsletten AE
中科院分区：
文献类型：
--
作者：
Sidorchuk A;Brander G;Pérez-Vigil A;Crowley JJ;Larsson H;Lichtenstein P;Mataix-Cols D;Nordsletten AE
母亲和父亲的精神疾病都与儿童学业成绩下降有关。然而，诊断类型和父母负担程度（例如，父母一方或双方受影响）对这些功能结局的差异影响尚不清楚。使用瑞典国家患者（NPR）和多代（MGR）登记册，对1973年1月1日至1997年12月31日出生的2 226 451名儿童（1 290 157对父母）进行了随访，直至2013年12月31日。所有队列成员的诊断状态被定义为11种精神疾病，并根据暴露情况对家庭进行分类：（1）父母患有任何疾病，（2）父母患有疾病组（例如神经精神疾病），（3）父母患有特定疾病（例如ADHD）。成对进一步定义为“未受影响”、“单一影响”或“双重影响”。在后代中，该研究评估了从义务教育（小学）到大学（学院）的四个学术里程碑的实现情况。敏感性分析认为，儿童自身的心理健康，以及父母的教育，对主效应的影响。在最早的学校教育阶段，单受影响者[调整后的优势比（aOR），0.50; 95%CI 0.49-0.51]和双受影响者的成绩优势明显降低。（aOR 0.29，95% CI 0.28-0.30），此后持续存在[aOR范围（单次），0.52-0.65; aOR范围（双次），0.30-0.40]。在诊断/诊断组内重复该模式进行分析。主要结果对子女心理健康和父母教育水平的调整是稳健的。父母精神疾病与下一代受教育程度的大幅下降有关，来自双重影响家庭的儿童处于特别高的风险之中。
Both maternal and, separately, paternal mental illness are associated with diminished academic attainment among children. However, the differential impacts of diagnostic type and degree of parental burden (e.g. one v. both parents affected) on these functional outcomes are unknown. Using the Swedish national patient (NPR) and multi-generation (MGR) registers, 2 226 451 children (1 290 157 parental pairs), born 1 January 1973–31 December 1997, were followed through 31 December 2013. Diagnostic status of all cohort members was defined for eleven psychiatric disorders, and families classed by exposure: (1) parents affected with any disorder, (2) parents affected with a disorder group (e.g. neuropsychiatric disorders), and (3) parents affected with a specific disorder (e.g. ADHD). Pairs were further defined as ‘unaffected,’ ‘single-affected,’, or ‘dual-affected.’ Among offspring, the study evaluated fulfillment of four academic milestones, from compulsory (primary) school through University (college). Sensitivity analyses considered the impact of child's own mental health, as well as parental education, on main effects. Marked reductions in the odds of achievement were observed, emerging at the earliest levels of schooling for both single-affected [adjusted odds ratio (aOR), 0.50; 95% CI 0.49–0.51] and dual-affected (aOR 0.29, 95% CI 0.28–0.30) pairs and persisting thereafter [aOR range (single), 0.52–0.65; aOR range (dual), 0.30–0.40]. This pattern was repeated for analyses within diagnosis/diagnostic group. Main results were robust to adjustment for offspring mental health and parent education level. Parental mental illness is associated with profound reductions in educational attainment in the subsequent generation, with children from dual-affected families at uniquely high risk.