Role of p38 and JNK in liver ischemia and reperfusion
Role of p38 and JNK in liver ischemia and reperfusion
复制标题
DOI：
10.1007/s00534-009-0155-x
复制
发表时间：
2009-11-01
期刊：
影响因子：
--
通讯作者：
Toledo-Pereyra, Luis H.
中科院分区：
文献类型：
--
作者：
King, LaShonda A.;Toledo, Alexander H.;Toledo-Pereyra, Luis H.
丝裂原活化蛋白激酶（MAPK）的信号转导已被认为是缺血相关事件的重要介质。正因为如此，我们分析了p38和JNK在肝脏缺血和再灌注中的参与，作为MAPK蛋白家族的两个独立成员，分析了PubMed过去15年中引用的所有论文，以确定这些MAPK如何以及何时被认为是缺血事件的复杂部分。交叉研究文献，以确定是否可以在文献中找到其他文件，p38和JNK在肝缺血中的作用在文献中得到证实。这些介质的激活与细胞凋亡和坏死的诱导有关。p38和JNK抑制剂可能通过上述机制减轻肝脏缺血再灌注损伤，开发有效的p38和JNK抑制剂对减轻肝脏缺血再灌注损伤具有重要意义。
The signal transduction of mitogen-activated protein kinases (MAPKs) has appeared to be an important mediator of ischemic-related events. Because of this, we analyzed the participation of p38 and JNK in liver ischemia and reperfusion, as two individual members of the MAPK family of proteins.All papers referred to in PubMed for the past 15 years were analyzed to determine how and when these MAPKs were considered to be an intricate part of the ischemic event. References were cross-studied to ascertain whether other papers could be found in the literature.The role of p38 and JNK in liver ischemia was confirmed in the literature. The activation of these mediators was associated with the induction of apoptosis and necrosis. Inhibitors of p38 and JNK reduced the liver ischemia and reperfusion damage, probably through the mechanisms mentioned before.The development of effective inhibitors of p38 and JNK protein mediators is important for minimizing the harmful effects associated with liver ischemia and reperfusion.