Synthesis and characterization of the 7-(4-aminomethyl-1H-1,2,3-triazol-1-yl) analogue of kabiramide C.
Synthesis and characterization of the 7-(4-aminomethyl-1H-1,2,3-triazol-1-yl) analogue of kabiramide C.
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DOI：
10.1021/np049670z
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发表时间：
2005-02
影响因子：
5.1
通讯作者：
Chutima Petchprayoon;K. Suwanborirux;Reagan L. Miller;T. Sakata;G. Marriott
中科院分区：
文献类型：
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作者：
Chutima Petchprayoon;K. Suwanborirux;Reagan L. Miller;T. Sakata;G. Marriott
采用Mitsunobu反应和1,3-偶极环加成法制备了卡比酰胺C(5)的7-（4-氨基甲基- 1h -1,2,3-三唑-1-基）类似物。该化合物和中间化合物2和4与g -肌动蛋白紧密结合，呈1:1的复合物，并表现出与1相同程度的细胞毒性。化合物5是合成肌动蛋白导向光学探针和药物的关键中间体。
The 7-(4-aminomethyl-1H-1,2,3-triazol-1-yl) analogue of kabiramide C (5) was synthesized by using the Mitsunobu reaction and 1,3-dipolar cycloaddition. This compound and the intermediate compounds 2 and 4 were shown to bind tightly to G-actin in a 1:1 complex and exhibited the same degree of cytotoxicity as 1. Compound 5 serves as a key intermediate for the synthesis of actin-directed optical probes and drugs.