Microbiology of otorrhea in children with tympanostomy tubes: implications for therapy
Microbiology of otorrhea in children with tympanostomy tubes: implications for therapy
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DOI：
10.1016/j.ijporl.2003.08.043
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发表时间：
2003-12-01
影响因子：
1.5
通讯作者：
Dohar, J
中科院分区：
文献类型：
--
作者：
Dohar, J
目的：基于鼓膜造口管儿童发生耳畸形的患病率，进行了一项分析，以确定该人群的特定预后指标，使临床医生能够确定特定病原体的可能性，并选择最佳的经验性治疗。方法：数据来自两个多中心临床。氧氟沙星耳用溶液0.3%（OFLX）在1-12岁儿童患者中的临床试验被用于制定统计学。模型来预测外耳道（EAC）或鼻咽（NPG）病原体的可能性。283例微生物学可评价患者的数据可用。潜力指标包括受试者年龄、入组季节、耳抽吸、清洁、耳炎和肉芽组织。该模型采用逐步逻辑回归分析，将NPG或EAC病原体的发生与潜在的预后指标联系起来。结果：在总研究人群中，42.8%和61.5%分别有NPG和EAC病原体，10.6%两者都有。最常见的有效病原体是肺炎链球菌和流感嗜血杆菌。NPG病原体的重要预后指标是受试者年龄、入组季节和耳气味的存在。尽管EAC和NPG病原体的这些指标相似，但相关性是相反的，即老年受试者有EAC病原体，而年轻受试者有（
Objective: Based on the prevalence of children with tympanostomy tubes who develop otorrhea, an analysis was performed to identify specific prognostic indicators in this population to enable clinicians to determine the likelihood of specific pathogens and select the best empiric therapy. Methods: Data from two multicenter clinical. trials of ofloxacin otic solution 0.3% (OFLX) trials in pediatric patients 1-12 years of age were used to develop a statistical. model to predict the likelihood of external auditory canal (EAC) or nasopharyngeal (NPG) pathogens. Data were available for 283 microbiologically evaluable patients. potential. indicators included subject age, season of enrollment, ear aspiration, cleaning, otorrhea, and granulation tissue. The model used a stepwise logistic regression analysis relating the occurrence of NPG or EAC pathogens to the potential prognostic indicators. Results: Among the total study population, 42.8 and 61.5% had NPG and EAC pathogens, respectively; 10.6% had both. The most frequently isolated valid pathogens were Streptococcus pneumoniae and Haemophilus influenzae. Significant prognostic indicators for NPG pathogens were subject age, season of enrollment, and presence of ear odor. Although these indicators were similar for EAC and NPG pathogens, the correlation was reversed, i.e. older subjects had EAC pathogens, and younger ones (