IMMUNOGENICITY OF HEPATITIS-B VIRUS-VACCINE IN HEALTHY CHINESE NEONATES
IMMUNOGENICITY OF HEPATITIS-B VIRUS-VACCINE IN HEALTHY CHINESE NEONATES
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DOI：
10.1093/infdis/148.3.526
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发表时间：
1983-01-01
影响因子：
6.4
通讯作者：
LEE, TY
中科院分区：
文献类型：
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作者：
LEE, GCY;HWANG, LY;LEE, TY
对38例健康易感新生儿（23例）和血清抗乙型肝炎表面抗原（anti-HBs）被动抗体15例进行了乙型肝炎疫苗免疫原性研究。最初，每个婴儿通过肌肉注射途径接受两次20微克剂量的疫苗，两次剂量之间间隔一个月。未发生不良反应，所有易感新生儿抗体反应活跃，与大龄婴儿和儿童相当，优于成人。第一剂疫苗刺激了48%的新生儿在一个月内产生抗乙肝病毒。91%的疫苗接种者在3个月大时（即第二次接种后2个月）的血清中可检测到抗hbs。到6个月大时，96%的疫苗接种者血清中可检测到抗hbs。所有的疫苗接种者在7个月大时接种第三剂后都产生了抗乙肝病毒。在最初有被动抗体的婴儿接种疫苗后，高水平的抗hbs持续存在。
The immunogenicity of hepatitis B virus vaccine was studied in 38 Chinese neonates, 23 of whom were healthy and susceptible and 15 of whom had passive serum antibody to hepatitis B surface antigen (anti-HBs). Initially, each infant received two 20-µg doses of vaccine by the intramuscular route, with a one-month interval between doses. No adverse reactions occurred, and all susceptible neonates had a brisk antibody response that was comparable to that in older infants and children and superior to that in adults. The first dose of vaccine stimulated the production of anti-HBs within one month in 48% of the neonates. Anti-HBs was detectable in the serum of 91% of the vaccinees at the age of three months — that is, two months after the second dose. By the age of six months, 96% of vaccinees had detectable anti-HBs in their serum. All vaccinees developed anti-HBs after a third dose was administered at the age of seven months. High levels of anti-HBs were sustained after vaccination in infants who initially had passive antibodies.