Neutrophil chemotaxis in families with localized juvenile periodontitis.
Neutrophil chemotaxis in families with localized juvenile periodontitis.
复制标题
局限性幼年牙周炎家族中的中性粒细胞趋化性。
DOI：
10.1111/j.1600-0765.1985.tb00834.x
复制
发表时间：
1985
影响因子：
3.5
通讯作者：
Genco,RJ
中科院分区：
文献类型：
--
作者：
VanDyke,TE;Schweinebraten,M;Cianciola,LJ;Offenbacher,S;Genco,RJ
局限性青少年牙周炎（LJP）的特征是严重的、早发性牙槽骨丢失，局限于第一磨牙和切牙，伴放线放线杆菌感染和相关的中性粒细胞功能异常的高患病率。由于这种情况经常发生在家庭，这是本调查的目的，以确定中性粒细胞趋化性异常和临床牙周病的LJP家庭的关联。研究了22个家族，其中先证者是根据LJP的表现选择的。所有的同胞进行了检查的存在下LJP和中性粒细胞趋化性进行了测量。结果表明，LJP和中性粒细胞趋化性障碍有很高的相关性，并且这种相关性在沿着家族系是一致的。特别是，在先证者表现出中性粒细胞趋化性障碍的家庭中，所有受影响的兄弟姐妹（LJP）也表现出中性粒细胞趋化性下降，而超过青春期年龄的未受影响的兄弟姐妹则表现出正常的中性粒细胞趋化性。另一方面，在先证者（LJP）表现出正常趋化性的家庭中，正常和受影响的兄弟姐妹都表现出正常的趋化性。在LJP家族中发现，一些表现出中性粒细胞趋化性抑制，而另一些表现出正常的中性粒细胞，这表明LJP的异质性。因此，有人提出，有一个综合征的家族性局限性青少年牙周炎与抑制中性粒细胞趋化性和另一种形式的家族性局限性青少年牙周炎与正常中性粒细胞趋化性。趋化性障碍和LJP发生在LJP家族中近一半的兄弟姐妹中。这与显性特征一致然而，需要进行多代研究，以确定遗传方式。因此，中性粒细胞趋化性是一种疾病标志物，可用于遗传学研究的家族性LJP与抑制中性粒细胞趋化性。此外，在先证者表现出中性粒细胞趋化性缺陷的家族中，青春期前的兄弟姐妹经常表现出这种缺陷。由于青春期前的兄弟姐妹不受临床检测LJP，中性粒细胞趋化性抑制在这些儿童中的发现进一步表明，中性粒细胞趋化性缺陷是遗传的起源，之前，并可能倾向于局部青少年牙周炎。
Localized juvenile periodontitis (LJP) is characterized by severe, early onset alveolar bone loss, localized to the first molars and incisors and a high prevalence of infection withActinobacillus actinomycetemcomitansand associated neutrophil functional abnormalities. Due to the frequent occurrence of this condition in families, it was the purpose of this investigation to determine the association of neutrophil chemotaxis abnormalities and clinical periodontal disease in families with LJP. Twenty‐two families were studied in which the proband was selected based upon presentation of LJP. All siblings were examined for the presence of LJP and neutrophil chemotaxis was measured on all subjects. The results indicate that there is a high association of LJP and neutrophil chemotaxis disorders and that this association is consistent along family lines. Specially, in families in which the proband exhibits a neutrophil chemotaxis disorder, all affected siblings (LJP) also exhibit depressed neutrophil chemotaxis, whereas, non‐affected siblings beyond the age of puberty have normal neutrophil chemotaxis. On the other hand, in families where the proband (LJP) exhibits normal chemotaxis, both normal and affected siblings exhibit normal chemotaxis. The finding among families with LJP that some exhibit neutrophil chemotactic depression and others exhibit normal neutrophils suggests heterogeneity of LJP. Accordingly, it is proposed that there is a syndrome of familial localized juvenile periodontitis with depressed neutrophil chemotaxis and another form of familial localized juvenile periodontitis with normal neutrophil chemotaxis. The chemotaxis disorder and LJP occur in nearly one‐half of the siblings in families with LJP. which is consistent with a dominant trait. however, multigenerational studies are necessary to determine the mode of inheritance. Hence, neutrophil chemotaxis is a disease marker which can be used in genetic studies of familial LJP with depressed neutrophil chemotaxis. Furthermore, prepubertal siblings often exhibit defective neutrophil chemotaxis in the families in which the proband exhibits such a defect. Since the prepubertal siblings are not affected by clinically detectable LJP, the finding of neutrophil chemotactic depression in these children further suggests that the neutrophil chemotactic defect is genetic in origin, precedes and may predispose to localized juvenile periodontitis.